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14 Cards in this Set

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List 3 generalities common to the herpesviridae. of Herpes viruses?
1. They can develop a latent stste.
2. Members in the subfamily alpha have a cytopathic effect on cells, which become multinucleated giant syncytial cells with intranuclear inclusion bodies.
3. herpesviridae are held at bay by the cell mediated immune response.
Regarding latency of the herpes virus, during the primary infection the viruses migrate up the nerves to the sensory ganglia and reside there. TRUE/FALSE
TRUE.
What is the cytopathic effect of herpes viruses/
The herpes viridae that cause cell destruction are the alpha subgroup viruses(simplex 1 and 2) and varicella zoster. This results in the separation of the epithelium and causes blisters(vesicles). scrapings from blister bases in herpes reveal intranuclear inclusion bodies, and multinucleated giant cells. Inclusions are loci of viral assembly.
Antibodies to HSV-1 are present in 90% of adults by the fourth grade. TRUE/FALSE
TRUE.
When there are clinical symptoms, patients may present with 4 symptoms. What are they?
1.Gingivostomatitis
2.Reactivation
3.Herpetic keratitis
4.Encephalitis-HSV-1 is the most common cause of viral encephalitis in the US. It is a treatable disease if caught early.
What is HSV-2?
It is antigenically distinct from HSV-1. It causes genital disease that is sexually transmitted.
HSV-2 can also cause oral/skin/eye disease and HSV-1 can cause genital herpes.
HSV infection during pregnancy can result in transplacental viral transfer. TRUE/FALSE
TRUE. IT can result in birth defects and intrauterine death.
herpes is one of thr TORCHES diseases that can cross the blood placenta barrier. TRUE/FALSE
TRUE. TORCHES
TOxoplasmosis
Rubella
Cytomegalovirus
HErpes
Syphilis
What is Varicella-Zoster Virus(VZV)?
This virus causes 2 diseases;
varicella(chickenpox)
herpes zoster(shingles).
What is Varicella?
VZV is highly contagious, infecting up to 90% of those exposed. It occurs in epidemics. App. 90% of the population has had exposure.
It infects the respiratory tract and replicates for a 2 week incubation period, followed by viremia.
What are the symptoms of varicella?
Fever, malaise and headache are followed by the characteristic rash. The vesicles scab in about 7-10 days, and the patient is no longer contagious.
What is Zoster (Shingles)?
Following a stressed state or lowered immune status, the latent varicella zoster virus in the sensory ganglion begins to replicate and migrate to the peripheral nerves. Burning painful skin lesions develop over the area supplied by the sensory nerves.
A vaccine has been developed for varicella zoster. TRUE/FALSE
TRUE. Its use in children is controversial due to the mildness of the disease.
In immunocompromised patients a zoster immune globulin may be given, which consists of antobodies against VZV isolated from patients. It must be given early.
Intravenous acyclovir, appears to decrease the severity and duration of the infection. TRUE/FALSE
TRUE.