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10 Cards in this Set

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  • Back
What do Yersinia, Franciscella, Brucella, and pasteurella have in common?
They are all G- rods(bacilli)
Are zoonotic diseases.
Yersinia, Francisella and Brucella are very virulent, and can penetrate any body area they touch. TRUE/FALSE
TRUE. Bacteria are phagocytosed by macrophages, and can survive inside, and are facultative intracellular organisms. they can regionalize in lymphnodes as well as the liver, spleen and lungs.
What is the common therapy/
Aminoglycosides(gentamicin/streptomicin) and/or doxycycline.
What is Yersinia pestis?
This was responsible for the Bubonic plague in Europe. There was a breakout in the 1900's in San Francisco. Today it resides in squirrels and prarie dogs of the southwestern US.
Does it possess virulence factors?
Yes. Fraction 1(F1)-This capsular antigen has antiphagocytic properties.
V/W antigens-These antigens which are a protein and a lipo-protein are unique to yersinia genus. They have been positively identified, yet their actions are unclear.
Yersinia has a bipolar staining pattern. TRUE/FALSE
TRUE. It is Gram-. The ends of the rod stain darker than does the center. It is spread by flea bloodmeals. It is not as commonly diagnosed in interepidemic periods.
What is its pathogenesis?
The bacteria invade the skin and are ingested by macrophages. They reproduce intracellularly and within a week move to the nearest lymphnode, usually the inguinal(boubon is the greek for groin. Fever and headache will set in. The bacilli invade the bloodstream. hemorrhages under the skin cause a blackish discoloration.(Black Death). About 755 of untreated patients die. if only the rats are killed, the fleas will assault humans.
Yersinia enterocolitica infects the colon and is closely related to E. coli. TRUE/FALSE
What is Tularemia?
It is a disease that resembles bubonic plague. It is most commonly acquired from handling infected rabbits and from the bites of ticks and deerflies. The causative agent is Francisella tularensis.
List 2 important diseases caused by Francisella tularensis?
1. Ulceroglandular tularemia; after a bite by a tick or deerfly, or wild rabbit contact, fever develops and lymphnodes enlarge and drain. The skin ulcer is usually absent in the plague and the mortality rate is not as high.
2. Pneumonic tularemia- Aerosolization of bacteria during skinning and evisceration of an infected rabbit or hematogenous spread. Just 10 organisms can cause disease, and most labs will not culture blood or pus samples.