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8 Cards in this Set

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Describe the morpholgy and special characteristics of Listeria?
Smal Gram + bacillus, facultative intracellular, beta-hemolysis, catalase positive, tumbling motility at room temperature.
What is unique about the growth characteristic of Listeria?
It frows well in cold temperature(4-10C)
What is the most prominant virulence factor in Listeria?
Listeriolysin O toxin penetrates host cells phagocytic vacuole to facilitate entry into the cytoplasm.
What is unique about the mechanism in which Listeria infects cells?
Listeria has the ability to spread from cell to cell without entering the extracellular environment by using an actin polymerization propulsion system.
What diseases are caused by Listeria?
Meningoencephalitis, sepsis, infections in pregnancy and gastroenteritis.
What patient populations are typically affected by Listeria?
Pregnant women, newborns of infected mothers, elderly and immunosuppressed patients. It is a facultative intracellular organism and requires an intact cell mediated immunity to clear.
How is Listeris transmitted?
Most commonly via unpasteurized dairy meats and vegetables. Also transplacental spread during delivery.
How is Listeria treated?
Ampicillin(with gentamicin for serious cases or trimethoprim-sulfamethoxazole, for penicillin allergic patients. It is always resistant to cephalosporins.