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9 Cards in this Set

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Does C. diphtheriae form spores or have a capsule?
No. It is a non spore forming and non encapsulated.
What disease is caused by C. diphth?
Diphtheria. Lymphadenopathy(bull neck) and pseudomembrane pharyngitis(thick, gray exudative pseudomembrane in the throat and nasopharynx).
How is C. diphtheria transmitted?
Via airborne droplets.
HOw is C. diphtheria exotoxin encoded?
Beta prophage DNA.
What is exotoxin's mechanism of action?
ADP ribosylation of elongation factor-2(EF-2) which blocks tRNA translocation causing inhibition of host protein synthesis.
What are the major complications of Diphtheria?
Physical airway obstruction, myocarditis, demyelination, paralysis of peripheral nerves.
What type of agar is used for culturing C. diphtheria?
Tinsdale potassium tellurite agar.
How is C. diphtheria diagnosed?
Lab diagnosis is based on Gram + rods with metachromatic(blue and red) granules.
How is C. diphtheria treated?
Immediate administration of horse serum antitoxin and antibiotics(penicillin G and erythromycin).
Prevented with DTaP vaccine.