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9 Cards in this Set
- Front
- Back
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Does C. diphtheriae form spores or have a capsule?
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No. It is a non spore forming and non encapsulated.
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What disease is caused by C. diphth?
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Diphtheria. Lymphadenopathy(bull neck) and pseudomembrane pharyngitis(thick, gray exudative pseudomembrane in the throat and nasopharynx).
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How is C. diphtheria transmitted?
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Via airborne droplets.
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HOw is C. diphtheria exotoxin encoded?
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Beta prophage DNA.
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What is exotoxin's mechanism of action?
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ADP ribosylation of elongation factor-2(EF-2) which blocks tRNA translocation causing inhibition of host protein synthesis.
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What are the major complications of Diphtheria?
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Physical airway obstruction, myocarditis, demyelination, paralysis of peripheral nerves.
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What type of agar is used for culturing C. diphtheria?
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Tinsdale potassium tellurite agar.
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How is C. diphtheria diagnosed?
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Lab diagnosis is based on Gram + rods with metachromatic(blue and red) granules.
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How is C. diphtheria treated?
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Immediate administration of horse serum antitoxin and antibiotics(penicillin G and erythromycin).
Prevented with DTaP vaccine. |
