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6 Cards in this Set

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  • Back
Name three pathologic manifestations of B anthracis.
1. Cutaneous anthrax by contact with animal products contaminated with spores.
Name the three virulence factors of B. anthracis and describe their mechanisms of action.
Capsule is antiphagocytic. Edema factor exotoxin is a calmodulin dependent adenylate cyclase that increases cyclic adenosine monophosphate(cAMP) causing severe edema.
Lethal factor exotoxin is a protease, causing cells to increase TNF production leading to cell death.
What are the clinical symptoms of cutaneous anthrax?
Black painless papules and pustules erupt on skin surfaqce, spreading to lymphnodes and blood, resulting in sepsis. Mortality rate is 20% if untreated.
What are the clinical symptoms of pulmonary anthrax?
First stage(2-3days) consists of influenza like symptoms such as dry cough, fever and aches.
Second stage, given by difficulty breathing, substernal pressure due to bloody pleural effusion and sepsis.
Chest X ray shows widening of the mediastinum. Mortality is 100% if untreated.
What are the clinical symptoms of GI anthrax?
Bloody, vomiting and diarrhea, abdominal pain ,fever. Mortality is 25-60%.
How is anthrax usually treated?
Penicillin, tetracyclines and fluoroquinolones.