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9 Cards in this Set

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What species of bacteria causes a nontender ulcer that heals spontaneously after 2-6 weeks?
Treponema pallidum
Describe the stages of syphilis.
1. Primary syphilis presents with a painless chancre on the penis or labia and lasts 3-6 weeks.
2. Secondary syphilis presents 1-3 months later after hematogenous spread of the organisn and manifests as a skin rash that includes the palms soles, as well as condyloma lata, a a flat wart like lesion in the intertrigenous regions(near theanus).
3. Tertiary syphilis occurs years later in about 30% of untreated patients and can present with aortitis, tabes dorsalis and gummas.
How is syphilis diagnosed?
Venereal disease research laboratory(VDRL)(nonspecicfic), rapid plasma reagin(RPR)(nonspecific) and fluorescent treponemal antibody absorbed(FTA-ABS)(specific).
Which test remains positive for life after infection?
FTA-ABS
What type of staining microscopy is needed to adequately visualize T. pallidum?
Darkfield microscopy is used to visulaize the treponemas.
What is the treatment of choice for T. pallidum infection?
Penicillin G.
What is the Jarisch-Herxheimer reaction?
A self resolving reaction that occurs after antibiotic treatment for a spirochete disease and manifests as an increase in temperature, decrease in blood pressure, rigors, and leukopenia, headache, chills, malaise, it results from the release of treponemal cell wall products after lysis by the antibiotics.
The liklihood of fetal infection during pregnancy can be decreased if the T. pallidum infection is treated before what stage of gestation?
T. pallidum infection does not seem to damage the fetus until after 20 weeks of gestation.
Describe the ocular lesion commonly found in syphilis?
Argyll-Robertson pupil is caused by a midbrain lesion, leading to a pupil that constricts during accommodation, but not to light.