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18 Cards in this Set
- Front
- Back
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What is the pathology of Crohn's disease?
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-Massive inflammatory cell influx
-Hemorrhage -damage of blood vessels and gut wall |
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What does the pathologic inflammation in Crohn's disease lead to in the majority of patients?
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The need for surgery in their lifetime.
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Maximum area of bacterial colonization in the GI tract:
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-Terminal ileum
-Proximal cecum |
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Where is the highest incidence of pediatric IBD in the world?
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In wisconsin
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What is one of the most effective strategies for taking care of patients who have chronic inflammation?
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TNF-alpha antibody
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What is the TNF-alpha antibody?
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Infliximab
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Does TNF-a antibody work for Crohn's disease or Ulcerative colitis?
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Either
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What is not a maintainance therapy for patients with chronic inflammation?
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Corticosteroids
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What is essential for the development of chronic inflammation in Crohn's and UC?
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The presence of bacteria in the gut
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So the therapy for Crohn's and UC fistulizing and lumenal disease is:
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Anti-TNF alpha (Infliximab)
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Highest locations of bacteria in the gut are:
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-Terminal ileum
-Cecum |
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HIghest pediatric IBD incidence is:
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In wisconsin
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% of IBD patients who will need surgery:
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90%
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What is a symptom of Crohn's that is NOT seen in UC?
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Granulomatous inflammation
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Animal models require ______ for the development of IBD:
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Gut normal flora
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_______ will become a risk factor for patients who have simmering inflammation:
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Adenocarcinoma of the colon
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Why are patients with IBD at risk for developing adenocarcenoma of the colon?
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IBD is the 2nd most common powerful risk factor for its develpment
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_________ are not effective in the maintainance of patients with Crohn's and UC:
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Corticosteroids
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