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25 Cards in this Set

  • Front
  • Back
What is the predominate type of bacteria on the body?
anaerobes (both obligate and facilitative)
do anaerobes grow on 10% Co2?
no they do not
What is the energy source for anaerboes?
fermentation, or anaerobic respiration
What conditions are best for anaerobes?
acidic conditions and low oxygen tension
Generally, what group of bugs cause the exogenous anaerobic infections?
clostridium
What is a main sign of anaerobic infection?
putrid odor, with discharge
What is the morphology of the bacteroides group?
common non spore forming*
opportunisitc anaerobic pathogen
BILE-resistant**
What is the MOST common cause of intra abdominal infection?
Bacteroides fragilis (G- bacillus, anaerobic)
What does bacteroides fragilis lack in its LPS?
No lipid A- which makes it less toxic than other gram negatives
What are the virulence factors of Bacteroides fragilis
Polysaccharide capsule

fimbriae

B-lactamase**

ineducable SOD/catalase***

Succinic acid- inhibits neutrophils

IgA protease
What type of infections does bacteroides fragilis usually result in?
endogenous infections
How does bacteroides fragilis usually spread?
this is non invasive,
so it spreads by trauma or a disease state
What are the clinical signs of Bacteroides Fragilis?
this seems like appendicitis-

deep pain/ tenderness
sudden and severe abdominal pain
What is the treatment for Bacteroides Fragilis?
drain abscess, remove necrotic tissue.

DOC- metronidazole, clindamycin, augmentin,
What is the shared morphology of Porphyromonas and Prevotella?
2nd common anaerobic pathogens when found together

encapsulated

STRONG LPS**

IgA, IgG, IgM proteases**
What are the clinical manifestations of Porphyromonas infections?
gingival and periapical tooth infections

isolated infections in the breast, axilla, perianal, and genital regions
What kinds of infections is prevotella melaninogenica responsible for?
URT's
What kinds of infections are Prevotella Bivia and Disiens responsible for?
female genital tract infections
What is the morphology of fusobacterium?
this is a G- bacilli
anaerobic
fusiform appearance
What are the common clinical manifestations of Fusobacterium?
Gingivitis
Noma (face eating gangrene)
osteomyelitis (monomicrobic)
What does "Anaerobic G+ Coccus" ALWAYS indicate?***
Peptostreptococcus
What are the clinical manifestations of peptostreptococcus?
Aspiration pneumonia

brain abscess**

GI/Wound infections
What clinical signs lead you to an Anaerobic infection?
infection contiguous with mucosal surface

severe sickly sweet smelling discharge

severe necrosis

abscess/gangene

Gas production- crepitis
What drugs can you NOT use for anaerobes?
aminoglycosides

Sulfa drugs (inhibits THF production)

Penicillin
What drugs CAN you use for anerobics?
Clindamycin

metronidazole

be sure to try and cover G-/G+ for polymicrobial infections