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25 Cards in this Set
- Front
- Back
What is the predominate type of bacteria on the body?
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anaerobes (both obligate and facilitative)
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do anaerobes grow on 10% Co2?
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no they do not
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What is the energy source for anaerboes?
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fermentation, or anaerobic respiration
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What conditions are best for anaerobes?
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acidic conditions and low oxygen tension
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Generally, what group of bugs cause the exogenous anaerobic infections?
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clostridium
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What is a main sign of anaerobic infection?
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putrid odor, with discharge
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What is the morphology of the bacteroides group?
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common non spore forming*
opportunisitc anaerobic pathogen BILE-resistant** |
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What is the MOST common cause of intra abdominal infection?
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Bacteroides fragilis (G- bacillus, anaerobic)
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What does bacteroides fragilis lack in its LPS?
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No lipid A- which makes it less toxic than other gram negatives
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What are the virulence factors of Bacteroides fragilis
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Polysaccharide capsule
fimbriae B-lactamase** ineducable SOD/catalase*** Succinic acid- inhibits neutrophils IgA protease |
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What type of infections does bacteroides fragilis usually result in?
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endogenous infections
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How does bacteroides fragilis usually spread?
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this is non invasive,
so it spreads by trauma or a disease state |
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What are the clinical signs of Bacteroides Fragilis?
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this seems like appendicitis-
deep pain/ tenderness sudden and severe abdominal pain |
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What is the treatment for Bacteroides Fragilis?
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drain abscess, remove necrotic tissue.
DOC- metronidazole, clindamycin, augmentin, |
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What is the shared morphology of Porphyromonas and Prevotella?
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2nd common anaerobic pathogens when found together
encapsulated STRONG LPS** IgA, IgG, IgM proteases** |
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What are the clinical manifestations of Porphyromonas infections?
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gingival and periapical tooth infections
isolated infections in the breast, axilla, perianal, and genital regions |
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What kinds of infections is prevotella melaninogenica responsible for?
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URT's
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What kinds of infections are Prevotella Bivia and Disiens responsible for?
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female genital tract infections
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What is the morphology of fusobacterium?
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this is a G- bacilli
anaerobic fusiform appearance |
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What are the common clinical manifestations of Fusobacterium?
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Gingivitis
Noma (face eating gangrene) osteomyelitis (monomicrobic) |
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What does "Anaerobic G+ Coccus" ALWAYS indicate?***
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Peptostreptococcus
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What are the clinical manifestations of peptostreptococcus?
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Aspiration pneumonia
brain abscess** GI/Wound infections |
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What clinical signs lead you to an Anaerobic infection?
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infection contiguous with mucosal surface
severe sickly sweet smelling discharge severe necrosis abscess/gangene Gas production- crepitis |
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What drugs can you NOT use for anaerobes?
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aminoglycosides
Sulfa drugs (inhibits THF production) Penicillin |
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What drugs CAN you use for anerobics?
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Clindamycin
metronidazole be sure to try and cover G-/G+ for polymicrobial infections |