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24 Cards in this Set

  • Front
  • Back
5 drugs that block protein synthesis (Tom Eats A Spicy Chicken for Protein)
tetracyclines - erythromycin - aminoglycosides - streptomycin - chloramphenicol
ribosomes difference in prokaryotes/eukaryotes
70s/80s
3 antibiotics made from streptomyces spp.
streptomycin - neomycin - kanamycin
streptomycin inserts on the ____ subunit & causes misreading of ____, ____ problems & ____ nerve damage
30s - mRNA - toxicity - auditory
streptomycin was the first drug for ____ but has little use today
TB
2 sides effects from taking aminoglycosides antibiotics are ____ problems & ____ ____ damage
toxicity - auditory nerve
tetracyclines block ____ on the __-____ site which stops synthesis
tRNA - A-acceptor
tetracycline is a ____ spectrum that blocks ____ ____
broad - protein synthesis
tetracyclines are bacterio-____ (static/cidal) & is used in animal ____
static - feed
tetracyclines are ____ (expensive/inexpensive)
inexpensive
2 tetracycline drugs taken orally for STDs, Rocky Mountain spotted fever, lyme disease, typhus, acne & protozoa
doxycycline - minocycline
2 side effects of doxycycline & minocycline, suppresses ____ ____ & ____ discoloration in kids
normal flora - teeth
chloramphenicol is made by ____ ____
streptomyces venzuelae
chloramphenicol is a ____ spectrum drug that blocks ____ bond formation (50s subunit)
broad - peptide
chloramphenicol no longer comes from ____ sources
natural
chloramphenicol is very _____ & have restricted use
toxic
chloramphenicol can cause ____ & ____ ____ damage
anemias - bone marrow
4 examples infections that are treated with chloramphenicol
typhoid fever - brain abscesses - rickettsial - chlamydial infections
erythromycins is a ____-lide & inhibits ____ ____
macrolide - protein synthesis
erythromycins are ____ spectrum & is bacterio-____ (static/cidal)
broad - static
erythromycins blocks ____ movement by attaching to ____ subunit
ribosome - 50s
erythromycins are low in ____ & are given to kids
toxicity
5 infections erythromycins are take orally for
mycoplasma pneumonia - legionellosis - chlamydia - perussis - diphtheria
2 newer semi-synthetics of erythromycin
clarithomycin - azithromycin