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24 Cards in this Set
- Front
- Back
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5 drugs that block protein synthesis (Tom Eats A Spicy Chicken for Protein)
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tetracyclines - erythromycin - aminoglycosides - streptomycin - chloramphenicol
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ribosomes difference in prokaryotes/eukaryotes
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70s/80s
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3 antibiotics made from streptomyces spp.
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streptomycin - neomycin - kanamycin
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streptomycin inserts on the ____ subunit & causes misreading of ____, ____ problems & ____ nerve damage
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30s - mRNA - toxicity - auditory
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streptomycin was the first drug for ____ but has little use today
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TB
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2 sides effects from taking aminoglycosides antibiotics are ____ problems & ____ ____ damage
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toxicity - auditory nerve
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tetracyclines block ____ on the __-____ site which stops synthesis
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tRNA - A-acceptor
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tetracycline is a ____ spectrum that blocks ____ ____
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broad - protein synthesis
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tetracyclines are bacterio-____ (static/cidal) & is used in animal ____
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static - feed
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tetracyclines are ____ (expensive/inexpensive)
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inexpensive
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2 tetracycline drugs taken orally for STDs, Rocky Mountain spotted fever, lyme disease, typhus, acne & protozoa
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doxycycline - minocycline
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2 side effects of doxycycline & minocycline, suppresses ____ ____ & ____ discoloration in kids
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normal flora - teeth
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chloramphenicol is made by ____ ____
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streptomyces venzuelae
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chloramphenicol is a ____ spectrum drug that blocks ____ bond formation (50s subunit)
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broad - peptide
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chloramphenicol no longer comes from ____ sources
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natural
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chloramphenicol is very _____ & have restricted use
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toxic
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chloramphenicol can cause ____ & ____ ____ damage
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anemias - bone marrow
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4 examples infections that are treated with chloramphenicol
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typhoid fever - brain abscesses - rickettsial - chlamydial infections
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erythromycins is a ____-lide & inhibits ____ ____
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macrolide - protein synthesis
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erythromycins are ____ spectrum & is bacterio-____ (static/cidal)
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broad - static
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erythromycins blocks ____ movement by attaching to ____ subunit
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ribosome - 50s
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erythromycins are low in ____ & are given to kids
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toxicity
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5 infections erythromycins are take orally for
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mycoplasma pneumonia - legionellosis - chlamydia - perussis - diphtheria
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2 newer semi-synthetics of erythromycin
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clarithomycin - azithromycin
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