Microbiology: Pathogenesis

Front 1

T/F: Colonization leads to disease

Back 1

FALSE... not necessarily

Front 2

A _______ is a colonization that leads to disease

Back 2

infection

Front 3

This is the DEGREE to which an organism can cause a disease

Back 3

Virulence

Front 4

This is the capacity of an organism to cause disease

Back 4

Pathogenicity

Front 5

This is the AGENT that promotes infection

Back 5

Virulence Factor

Front 6

___________ is a host's response to the agent

Back 6

immunopathology

Front 7

disease results when this step of Pathogenesis occurs

Back 7

damage

Front 8

what are the 6 steps of Pathogenesis?

Back 8

Entry
Spread
Multiplication
Damage
Outcome

Front 9

_____ pathogens cause disease even in healthy hosts

Back 9

True pathogens

Front 10

_____ pathogens cause disease under compromised or unusual conditions

Back 10

Opportunistic

Front 11

T/F: disease severity is dependent on both VIRULENCE or the organism and SUSCEPTIBILITY of the host

Back 11

True

Front 12

This is the Term that measures the # of organisms required to CAUSE infection in 50% of experimentally infected animals or cultured cells

Back 12

Infectious Dose (ID50)

Front 13

This is the # or organisms required to KILL 50% of experimentally infected animals or cultured cells

Back 13

Lethal dose

Front 14

T/F: A LOW ID 50 or LD 50 means a low Virulence factor

Back 14

FALSE: a low LD 50 = HIGH Virulence factor... means you need less to kill 50%

Front 15

BACTERIAL CONSTITUENTS that promote infection and subsequent disease

Adaptations to help the microbe invade and esablish itself in the host

Back 15

Virulence factor

Front 16

Active invasion involves bacterial _______ that promote entry into the host cell

Back 16

proteins

Front 17

Virulence factors inhibit phagocytosis by degredation of ___ so neutrophils can not migrate to the site

Back 17

C5a

Front 18

In _________ variation, genetic sequence is CHANGED so the protein is different

Back 18

Antigenic

Front 19

In _________ variation, gene encoding antigen is TURNED OFF

Back 19

Phase

Front 20

This is a negetive Virulence factor that can be used strictly for the release or spread of the bacteria

Ex. Streptokinas and Staphlokinase break down blood clots.

Hyaluronidase/ collagenase

Back 20

Spreading factors

Front 21

These are released from the cell either through secretion or cell lysis

Functions:
kill host cells
disrupt signaling
prevent antigen presentation

Back 21

Exotoxins

Front 22

In A-B Exotoxins, the __ Domain contains the enzymatic ACTIVITY (what it does to the cell)

Back 22

A Domain

Front 23

In A-B Exotoxins, the __ Domain contains the BINDING properties (Which cell is affected)

Back 23

B domain

Front 24

These are proteins that indiscriminately activates large numbers of T cells

Back 24

Superantigens

Front 25

This Virulence factor leads to septic shock, multiple system organ failure, and death

Back 25

Superantigen

Front 26

T/F the more virulence factors an organism has, the more likely it is to cause disease

Back 26

TRUE