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36 Cards in this Set
- Front
- Back
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Type of immunity whose intensity does not increase upon repeated exposure to organism:
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Innate (nonspecific) Immunity
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Macrophages and granulocytes are types of ________.
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Phagocytes
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Obtained by injection of an antigen
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Active immunity
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Obtained by injection of a serum from immune donor to a non-immune recipient
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Passive immunity
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Immunity effected by antibodies (IGs) in the serum, requires antigen presenting cells, T cells and B lymohocytes
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Humoral Immunity
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Response does not require B cells or antibodies- cannot be passively transferred with serum
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Cell mediated immunity
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Produced and secreted by Th cell, stimulates antibody production by B cells and cytotoxic activity of T cells, NK and macrophages
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Cytokines- produced by Thymus derived helper cells
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Most prominent cell in acute inflammation:
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Neutrophils (Phagocyte)
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Type of phagocyte that are abundant at sites of IgE mediated allergic reactions and parasitic organisms (helminths)
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Eosinophils
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Contain basic granules (histamine) and react to IgE and are found in a variety of tissues:
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Mast Cells
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Circulating precursor to macrophages
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Monocytes
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Secrete cytokines (IL-1, IL-6) and express adhesion molecules, both of which act as signals in T Cell activation
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Macrophages
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These cells have characteristic long dendrites and high antigen presenting function
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Dendritic Cells
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Major functions are antigen binding and signal transduction
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T cell receptor and CD3
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Major function is lineage specific marker
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CD2, CD5
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Major function is interaction with Class II MHC
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CD4
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Major Function is interaction with Class I MHC
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CD8
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Major function is activation-induced ligangds/receptors
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CD29, CD69, CD40L
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Major function is cytokine receptors
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Interleukins (ILs)
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Major Function is cell adhesion molecules
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LFA-1, ICAM
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Bursa or Bone marrow derived precursors of antibody secreting cells- can be identified by membrane expression of IG and CD19
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B Cells
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Lymphocytes derived from the Thymus and when mature express CD2 and CD3
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T Cells
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Produce a variety of cytokines that play a role in activation and proliferation of B cells, T cells and macrophages
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Helper T Cells
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Lymphocyte that can kill tumor cells, virus infected cells, allografts, etc.
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Cytotoxic T Cells
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Cells that inhibit immune responses and play a role in autoimmunity and limiting inflammatory response to prevent tissue damage
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Treg or regulatory T Cells
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Large granular lymphocytes with cytotoxic activity toward a variety of cell targets
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NK Cells
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This stem cell can differentiate into monocytes/macrophages, granulocytes and mast cells
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Myeloid stem cell
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This stem cell can differentiate in the bone marrow or spleen into B lymphocytes or can migrate to the thymus and be a T cell
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Lymphoid stem cell
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Hematopoiesis- proliferation and differentiation is _________ by cytokines
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Induced
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Site of T lymphocyte differentiation
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Thymus
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Responds to systemic infections, monitoring the blood
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Spleen
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Which part of the spleen contains macrophages and erythrocytes?
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Red Pulp
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Which part of the spleen forms periarterial sheaths of T lymphocytes?
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White Pulp
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Autosomal recessive disease characterized by poor inflammatory responses, recurrent infections, and impaired wound healing
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Leukocyte Adhesion Deficiency
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CAM that plays a critical role in cell adhesion and cell movement- provide hand holds for leukocytes and lymphocytes for crawling motility
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Integins
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Cell Adhesion Molecules with lectin like binding sites- bind to carbohydrate groups
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Selectins
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