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28 Cards in this Set
- Front
- Back
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Where is Coccidioidomycosis found?
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southwestern USA
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what is the morphology of Coccidioides immitis
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Spherule with endospores
and arthrospores on hyphae |
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what medium grows Coccidioides immitis?
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sabouraud agar
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what two antigens are used to immunodiagnose Coccidioides immitis?
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coccidioidin
spherulin |
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what does erythema nodosum (multiple skin lesion) with Coccidioides immitis indicate?
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a good prognosis, due to T-cells being fully functional and fighting back
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what are the symptoms of Coccidioides immitis?
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flu like symptoms-
can develop into pneumonia |
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What types of cells does a PAS stain try to look at in tissues?
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fungal cells
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What is the fungal stage of coccidomycossis
(TESTED) |
spherule with endosproes is the FUNGAL stage of coccidomycosis
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What groups of people are more likely to get Coccidioides immitis?
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American Indians
Asians African Americans Hispanics Pregnant people and Immundeficient people |
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How do you identify Coccidioides immitis?
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KOH for fresh sputum samples
PAS in fixed tisues Culture the mold @25C Beware of arthrospores |
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What antibodies can be used to identify Coccidioides immitis?
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IgM, IgG to coccidioidin and spherulin
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What is the treatment for Coccidioides immitis? (TESTED- know what structure it targets)
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fluconazole or amphotericin B (targets ergosterol)
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What is the actual infectious unit of histoplasma capsulatum?
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this is the microconidium
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what is the diganostic unit of histoplasma capsulatum? (in the lab)
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you look for tuberculate macroconidium projections
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how long does it take to culture histoplasma capsulatum?
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about 12 weeks
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how does histoplasma capsulatum spread?
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this spreads via the reticuloendotheilal system
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what form of histoplasma capsulatum is spread through the body?
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yest like cells are spread within macrophages. Note the budding!
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Where is histoplasma capsulatum common in the USA?
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Mississippi river valley area, Ohio
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What are the virulence factors for histoplasma capsulatum?
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Urease to raise pH (which inhibits phagolysosome activity)- which is how it travels in the reticuloendothelial system
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Is histoplasma capsulatum communicable?
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no it is not
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what animal has an association with histoplasma capsulatum
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Bat intestines
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how do you make the diganosis of histoplasma capsulatum?
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microscopic intracellular yeast
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what is the Tx of histoplasma capsulatum?
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itraconazole (or Azoles) and amphotericin B
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where is blastomyces dermatitidis found?
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in the ohio mississippi river valleys
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what is the morphology of blastomyces dermatitidis ?
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Broad Based Bud- very LARGE robust yeast cells
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Where is paracoccidioides brasiliensis found?
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confined to central and south america
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what does the yeast of paracoccidioides brasiliensis look like?
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multiple buds
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what is the key location for paracoccidioides brasiliensis?
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the andies mountians
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