Microbiology High Yield (Fa) - Part 5

Front 1

killed vaccines induce

Back 1

humoral immunity

Front 2

live/attenuated vaccines induce

Back 2

humoral immunity AND cell-mediated immunity

Front 3

live/attenduated vaccines

Back 3

VZV
Adenovirus
Smallpox
Sabin (oral, poliovirus)
Yellow fever
MMR

(Vaccines Are So Simple Yet Mandatory)

Front 4

live vaccines should not be given to

Back 4

immunocompromised pts. (or close contacts)

Front 5

killed vaccines

Back 5

Rabies
Influenza
Salk (IM, polio)
HAV

(RIP Always)

Front 6

egg-based vaccines

Back 6

Flu
mmR
Yellow fever

FRY an EGG

Front 7

negative-stranded RNA viruses

Back 7

Arenaviruses
Bunyaviruses
Paramyxoviruses
Orthomyxoviruses
Filoviruses
Rhabdoviruses

Always Bring Polymerase Or Fail Replication

[(-)RNA viruses require transcription of (-)RNA to (+)RNA via RNA polymerase]

Front 8

segmented RNA viruses

Back 8

Bunyaviruses
Orthomyxoviruses - 8 segments of (-)ssRNA
Arenaviruses
Reovirsuses

(BOAR)

Front 9

picornaviruses

Back 9

Poliovirus
Echovirus
Rhinovirus
Coxsackievirus
HAV

PERCH on a peak (pico-)

Front 10

virus:

orchitis = enlarged testes
aseptic meningitis
sterility (after puberty)

Back 10

mumps

(also parotitis)

Front 11

virus:

SSPE
encephalitis
giant cell pneumonia

Back 11

measles

(also head to toe rash with Koplik spots on buccal mucosa)

Front 12

3 C's of measles

Back 12

cough
coryza ("head cold")
conjunctivitis

Front 13

influenza A prophylaxis (2)

Back 13

amantadine

rimantidine

Front 14

MOA of amantadine and rimantidine

Back 14

inhibit M2 viral protein --> inhibition of viral uncoating

Front 15

influenza A and B treatment (2)

Back 15

oseltamivir

zanamivir

Front 16

MOA of oseltamivir and zanamivir

Back 16

neuraminidase inhibitors --> virus can't leave infected cell

Front 17

incubation period of rabies virus

Back 17

3 weeks to 3 months

Front 18

arboviruses (3)

Back 18

flaviviruses
bunyaviruses
togaviruses

(Flea Bites Today)

Front 19

yellow fever transmitted by

Back 19

Aedes mosquito

Front 20

virus:

black vomitus
jaundice
Councilman bodies (liver)

Back 20

yellow fever

Front 21

in addition to shingles, VZV can also cause (2)

Back 21

pneumonia
encephalitis

Front 22

HHV-8 transmitted via

Back 22

sexual contact

Front 23

nodes especially affected by EBV

Back 23

posteriorauricular

Front 24

atypical lymphocytes in EBV are

Back 24

cytotoxic T cells

Front 25

Tzanck test assays for (3)

looks for

Back 25

HSV-1
HSV-2
VZV

multinucleated giant cells

Front 26

HAV is a ______virus

Back 26

picornavirus

Front 27

HBV is a ______virus

Back 27

hepadnavirus

Front 28

HCV is a _______virus

Back 28

flavivirus

Front 29

HEV is a ______virus

Back 29

calicivirus

Front 30

hepatitis virus:

common cause of IV drug use hepatitis

Back 30

HCV

Front 31

HDV requires

Back 31

HBsAg

Front 32

hepatitis virus:

causes water-borne epidemics

Back 32

HEV

Front 33

hepatitis virus:

high mortality rate in pregnant women

Back 33

HEV

Front 34

hepatitis viruses:

predispose patients to chronic active hepatitis, cirrhosis, and hepatocellular carcinoma

Back 34

HBV
HCV

Front 35

best test to detect active HAV

Back 35

IgM HAVAb

Front 36

continued presence indicates HBV carrier state

Back 36

HBsAg

Front 37

provides immunity to HBV

Back 37

HBsAb

Front 38

positive during window period of HBV

Back 38

HBcAg

Front 39

indicator of recent HBV disease

Back 39

IgM HBcAb

Front 40

indicator of HBV transmissibilty

Back 40

HBeAg

(BEware)

Front 41

indicator of low HBV transmissibility

Back 41

HBeAb

Front 42

HIV envelope proteins (2)

Back 42

gp41

gp120

Front 43

HIV nucleocapsid protein

Back 43

gp24

Front 44

sensitive or specific:

ELISA for HIV

Back 44

sensitive

Front 45

sensitive or specific:

Western blot for HIV

Back 45

specific

Front 46

all babies born to HIV+ mothers have _______ detectable at birth

Back 46

anti-gp120 Ab's

Front 47

AIDS diagnosis:

CD count

CD4:CD8

Back 47

<200

<1.5 (normal 2.0)

Front 48

genotype of pts. immune to HIV

Back 48

homozygous for CCR5 mutation

Front 49

genotype of pts. who have slow course of HIV infection

Back 49

heterozygous for CCR5 mutation

Front 50

genotype of pts. who have rapid progression to AIDS

Back 50

CXCR4 mutation

Front 51

first HIV antigen detectable in pts. serum

Back 51

p24 antigen

Front 52

EBV in AIDS pt. causes (2)

Back 52

oral hairy leukoplakia

non-Hodgkin's lymphoma

Front 53

HIV gains access to the CNS via

Back 53

macrophages

Front 54

signs of HIV encephalitis (2)

Back 54

microglial nodules

multinucleated giant cells

Front 55

normal vs. pathologic prions

Back 55

normal prions - alpha helices

pathologic prions - beta pleated sheets