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20 Cards in this Set
- Front
- Back
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What are the presenting symptoms?
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1) fever
2) jaundice 3) dark yellow urine 4) pale colored stools 5) malaise 6) fatigue 7) abdominal pain 8) nausea AT SIGHT OF FOOD 9) loss of appetite |
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What is seen on physical exam?
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icterus with hepatomegaly and fever
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What is seen on blood work?
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high ALT to AST >500
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what genus is it? what family?
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1) hepatovirus
2) picornavirdae |
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What type genome and capsid does it have?
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it is a polyadenylated +ssRNA with a nonenveloped icosahedral capsid and contains its own RNA polymerase
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How many serotypes are there?
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1
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Can it be cultivated?
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yes it is the only one
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What is its major mode of transmission?
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fecal-oral
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Someone traveling in the gulf may acquire HAV because it is heavily concentrated in what?
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shellfish
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What is the average incubation period of HAV?
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30 days
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Are most infections asymptomatic?
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yes
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microscopically is it distinguishable from the other hepatitides?
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no
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Does the virus directly kill the hepatocytes?
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no it is an HAV-specific cytotoxic T cell response that results in damage
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Viremia begins within the first week of infection. When do liver enzymes peak?
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approximately 30 days
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In someone that has just developed jaundice is it possible to determine the peak of HAV infectivity?
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yes it occurs 2 weeks before onset of jaundice or elevated liver enzymes when the concentration of virus in the stool is highest
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At the onset of jaundice what happens to HAV concentrations in the stool?
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they decline
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what antibody is present 7 days before the onset of symptoms?
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IgM but can't be detected after 6 months
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IgG begins to appear about the 2-3 week and persists for how long?
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a lifetime
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What occurs in the chronic state of HAV?
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nothing because there isn't a chronic state
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How is it treated?
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it's not. Note that there is a vaccine available
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