Microbiology Exam Iii - Immune System

Front 1

how does skin prevent bacterial colonization

Back 1

dry
slightly acidic
keratinzed cells
sloughs off

lysozyme - degrades peptidoglycan
normal microbiota - compete for nutrients and colonization sites

langerhans cells

Front 2

this enzyme in sweat hair follicles and tears degrades peptidoglycan

Back 2

lysozyme

Front 3

these are dendritic cells of the skin - kill bact. where?

Back 3

langerhans cells

reside underneath epidermis in:
SALT - skin assoc lymph tissue

Front 4

defenses in Resp tract, GI tract, and Uroge tract?

Back 4

1. Mucus - traps and explled

Front 5

how does skin prevent bacterial colonization

Back 5

dry
slightly acidic
keratinzed cells
sloughs off

lysozyme - degrades peptidoglycan
normal microbiota - compete for nutrients and colonization sites

langerhans cells

Front 6

what proteins are there in mucus to protect?

Back 6

1. lysozyme
2. lactoferrin - sequesters iron from bact
3. defensins - toxic peptides put holes in bacteria
4. immune proteins - sIgA

Front 7

this enzyme in sweat hair follicles and tears degrades peptidoglycan

Back 7

lysozyme

Front 8

these are dendritic cells of the skin - kill bact. where?

Back 8

langerhans cells

reside underneath epidermis in:
SALT - skin assoc lymph tissue

Front 9

defenses in Resp tract, GI tract, and Uroge tract?

Back 9

1. Mucus - traps and explled

Front 10

what proteins are there in mucus to protect?

Back 10

1. lysozyme
2. lactoferrin - sequesters iron from bact
3. defensins - toxic peptides put holes in bacteria
4. immune proteins - sIgA

Front 11

this sequesters iron from bacteria. where in body/?

Back 11

lactoferrin
in mucus

Front 12

this kills bact by poking holes in membrane -Where?

Back 12

defensins
mouth tongue ingestine - in mucus

Front 13

These things bind and neutralize in mucus

Back 13

immne proteins - sec IgA

Front 14

all mucosal surfaces are protected by normal microbiota. T/F?

Back 14

no - uterus not uccupied

Front 15

What lies underneath mucus to help protect

Back 15

MALT - mucosa assoc lymph tissue
GALT - gastrointestinal a l t

make macroaph T cells B cells IgA

Front 16

what are the nonspecific defenders of the body

Back 16

phagocytes and nonspecific cytotoxic cells

Front 17

What are different kindso f phagocytes?

Back 17

1. polymorphomuclear leukocytes/neutrophils - short lived
2. monocytes - different into dendritic of macroph
3. macraph - chew up and present antgiens
4. dendrtic cells - chew up and present
5. mast cells - congregate around blood cells - vasodilation via histamine - increase circulation to aid in fight

Front 18

give example of cytotoxic cells?

Back 18

Natural killer cells - attacks infected cells

Front 19

this pathogen survives the lymph nodes (bact)

Back 19

yersinia pestis

Front 20

what are lysosomal components of phagocytes?

Back 20

degradative enzymes - lyso and prote

defensins - proe form

myelperoxidase -

Front 21

this protein guides where phagocytes should go

Back 21

cytokines and chemokines

Front 22

how do NK cells work?

Back 22

bind to target infected cell - release toxins contained with granules

1. perforin
2. granzymes - action protein through channels formed by perforin - stim apop

Front 23

What is main killer against bacteria? against virus?

Back 23

b - phagocytes - ingest with enzymes

V - NK cells induce apop

Front 24

diff btwn innate and adaptive immune sys

Back 24

innate - non specific attack to degrade pathogens - 1st line of defense - immediate

adaptive - memory response to specific pathogens - initiated when innate resp not adequate (4days) - lasting immunity

Front 25

these cells degreade and presnet antigens

Back 25

dendritic and macroph

Front 26

cells from bone marrow. function?

Back 26

B cells - produce antibodies

Front 27

lymph cells from thymus. fuction?

Back 27

T - cells - recognize antigens - stim cell medi immune resp

cytotoxic t cells (CD8) - kill infected cell
Helper T cells - help recog cell that is infected

Front 28

parts of antibody\

Back 28

constant heavy chain - binds to recptor on immune cells = Fc region

variable light chain - binds to antigen - always changing for recog and speci = V region

Front 29

this is teh process through which lymphocytes specific to disease are formed

how

Back 29

clonal selection

progenitor cell - makes diff lymphcytes each with diff specific

those that bind to self antigens are deleted

match with foreign antigen causes proliferation of a specifc lymph - clones of effector cells

Front 30

the promotion of ingestion and killing by phag cells

Back 30

opsonoization