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24 Cards in this Set
- Front
- Back
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acid fast characteristics
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mycolic acids, cell wall with high lipid content
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virulence factros M. tuberculosis
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replicates inside macrophages. Wax-D peptidoglycolipd (enhances immunogenity and delayted hypersensitivity)
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pathophysiology of M. tuberculosis
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symptomatic inhalation which localizes in the mid/lower lung. most people are asymptomatic
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epidiomiology of M tuberculosis
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a third of the world is infected. HIV, age, malnutrition, co-existing dieases, alcohol all signs
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disease of M. tuberculoss
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TB exposure - no evidence of infection
TB infection w/o disease - clear x-ray TB with infected disease - 80% pulmonary TB not clincally active - suggestive x-ray previoulsy diagnosed |
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lab diagnosis of M. tuberculosis
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Definitive ID = culture on Lowenstein-jensen meda, takes 6 weeks for +PPD to develop aftger exposure
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treatment of M. tuberulosis
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1st line - isoniazid, rifampin, pyrazinoamide, streptomycin, ethambutonol
2nd line - viomycin, kanamycin, capreomycin, cycloserine, ethionamide |
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PPD for tuberculosis
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5 mm postiive if HIV positive, chest x-ray positive, closoe contact with TB patients
10 mm positive recent immigrants, drug users, crowded facilities 15 mm positive for no factors |
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pathophysiology of nontuberculosis Mycobacteria
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M. meridum - saltwater tank
M. avium intracellulare - regular water |
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disease nontuberculosis Mycobacteria
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pulmonary disease, lymphadentis in children, superificial infection.
dissmeinated disease - M avium antracellulare loves AIDS patients |
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pathophysiology of M. leprae
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infets tissue colloer than 37 degress 0 skin, peripheral nerves, anteiror portion of eye, respiratory passage above larynx
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sources of M. leprae
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aramadillos, breast milk, biting insects
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disease of M. leprae
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lepromatous - lack of CMI granulomatous reaction with large macrophages filled with organisms
tuberculoid - few sharply dmearcated skin lesions, neurologic involvment borderline or dimorphous - combined of above |
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lab diagnosis of M. leprae
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cannot culture on synthetic media. can be grown on foot pads of mice in slow fashon
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treatment of M. leprae
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dapsone, rifampin, clofazimine, minocycline
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acid fastness A. bovis and israelii
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not acid fast by Zehli-Neelsen stain
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virulence factor A. israelii and bovis
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sulfa granules
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diseases of A. israellii and bovis
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cervicofacia' "lumpy jaw"
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lab diagnosis of A. israelii and bovis
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enriched media with CO2. gramstain, pleomorphic gram positive rods
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treatment A. israelii and bovis
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surgical drainage. penicillin or tetracycline
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temperature of N. asteroids and brasillensis
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wide temperature range
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pathophysiology of N. asteroides and brasillensis
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inhalation or would infection, soil
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disease of N. asteroides and brasillensis
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pulmonary (most common) disseminated wound infection
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treatment of N. asteroides and brasillensis
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sulfonamides, TMP_SXT
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