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15 Cards in this Set

  • Front
  • Back
superantigens - bind to what, activates what, releases what
bind directly to MHC II and Tcell receptor, activate T cells to stimulate release of IFN-gamma and IL-2
ADP ribosylating AB toxins - name 4 organisms
Corynebacterium diphtheriae
Vibrio cholerae
E. Coli
Bordetella pertussis
C. Diphtheriae mechanism
inactivates EF-2 (similar to pseudomonias exotoxin A).
Causes pharyngitis and pseudomembranes in throat
V. Cholerae mechanism
ADP ribosylation of G protein stimulates adenlyl cyclase, increases pumping of Cl, H2O into gut. causes RICE WATER diarrhea
E. Coli mechanism for each HL and HS toxins
Heat Labile toxin stimulates adenlate cyclase (cholerae like). cause watery diarrhea.
Heat stable toxin stimulates Guanylate cyclase.
"Labile like the air, stable like the ground"
Bordetella pertussis mechanism and what does it inhibit?
stimulate adenylate cyclase. whopping cough. inhibits chemokine receptor, causing lymphocytosis
Clostridium perfringins - toxin
alpha toxin. cause gas gangrene. double zone hemolysis
Shigella mechanism -2
Shiga toxin (also produced by E.Coli O157:h7) cleaves host cell rRNA. also enhance cytokine release, causing hemolytic uremic syndrome
Strep pyogene toxin
streptolysin O is hemolysin; antigen for ASO antibody in rheumatic fever
3 main actions of endotoxin
activates macrophages (IL-1, TNF, NO), Activates alternate complement pathway (C3a, C5a), activates Hageman factor (coagulation cascade, DIC)
what color pigments for following:
S. Aureus
Pseudomonas aeruginosa
Serratia marcescens
name 4 gram positive rods(bacilli)
clostridium (anaerobe)
Novobiocin sensitive gram positive,
Novobiocin resistant
sensitive - Staph epidermidis
Resistant - Staph saprophyticus
name 2 alpha hemolytic gram positives
strep pneumoniae
viridans streptococci (strep mutans)
name 2 beta hemolytic gram positives
strep pyogenes (group A)
strep agalactiae (group B)