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15 Cards in this Set
- Front
- Back
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superantigens - bind to what, activates what, releases what
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bind directly to MHC II and Tcell receptor, activate T cells to stimulate release of IFN-gamma and IL-2
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ADP ribosylating AB toxins - name 4 organisms
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Corynebacterium diphtheriae
Vibrio cholerae E. Coli Bordetella pertussis |
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C. Diphtheriae mechanism
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inactivates EF-2 (similar to pseudomonias exotoxin A).
Causes pharyngitis and pseudomembranes in throat |
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V. Cholerae mechanism
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ADP ribosylation of G protein stimulates adenlyl cyclase, increases pumping of Cl, H2O into gut. causes RICE WATER diarrhea
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E. Coli mechanism for each HL and HS toxins
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Heat Labile toxin stimulates adenlate cyclase (cholerae like). cause watery diarrhea.
Heat stable toxin stimulates Guanylate cyclase. "Labile like the air, stable like the ground" |
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Bordetella pertussis mechanism and what does it inhibit?
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stimulate adenylate cyclase. whopping cough. inhibits chemokine receptor, causing lymphocytosis
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Clostridium perfringins - toxin
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alpha toxin. cause gas gangrene. double zone hemolysis
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Shigella mechanism -2
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Shiga toxin (also produced by E.Coli O157:h7) cleaves host cell rRNA. also enhance cytokine release, causing hemolytic uremic syndrome
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Strep pyogene toxin
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streptolysin O is hemolysin; antigen for ASO antibody in rheumatic fever
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3 main actions of endotoxin
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activates macrophages (IL-1, TNF, NO), Activates alternate complement pathway (C3a, C5a), activates Hageman factor (coagulation cascade, DIC)
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what color pigments for following:
S. Aureus Pseudomonas aeruginosa Serratia marcescens |
yellow
glue-green red |
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name 4 gram positive rods(bacilli)
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clostridium (anaerobe)
Corynebacterium Listeria Bacillus |
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Novobiocin sensitive gram positive,
Novobiocin resistant |
sensitive - Staph epidermidis
Resistant - Staph saprophyticus |
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name 2 alpha hemolytic gram positives
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strep pneumoniae
viridans streptococci (strep mutans) |
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name 2 beta hemolytic gram positives
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strep pyogenes (group A)
strep agalactiae (group B) |
