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18 Cards in this Set
- Front
- Back
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CMV is what type of herpes?
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beta
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EBV is what type of herpes?
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gamma
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EBV persists within what cells?
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B cells
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What type of virus are CMV and EBV?
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herpesvirus; large, enveloped, dsDNA
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Latent EBV cells become active by expression of which set of genes? (Immediate early, early or late)
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immediate early cells start the progeny formation and progress the cycle
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Most common reasons babies get CMV?
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through mother's breast milk
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EBV enters a cell by attaching to what receptor?
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CD21
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COmpleted virions are released from the host cells via what process?
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exocytosis
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Why do phorbol esters lead to EBV reactivation?
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up-regulate gene expression in the latent cells in B cells
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CMV releases what cytokines o decrease host response?
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IL-8 and IL-10
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How does EBV avoid host response?
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glycine-alanine repeats on the major antigen that restrict antigen processing by the host
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Most common fetal viral infection
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CMV
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Atypical lymphocytes are seen in which pathology?
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EBV, also some in CMV
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EBV is linked to which malignancies?
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Hodgkin's and Burkitt's Lymphoma; nasopharyngeal carcinoma
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Hydrocephalus and retinitis are seen with which disease?
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CMV in infants (who are considered immunocompromised since they are not fully developed)
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Owl eye are indicative of which disease?
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CMV
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Name 2 CMV replication inibitors
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gancylcovir, foscarnet
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Ganciclovir and foscarnet mechanism
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phosphorylated by viral phosphotransferase > activated > inhibits viral DNA polymerase and terminates new viral DNA synthesis
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