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20 Cards in this Set
- Front
- Back
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What challenges do females present wrt to STDs?
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1. Biologically more susceptible
2. Often asymptomatic 3. More difficult to diagnose |
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What are the cellular characteristics of Gonorrhea?
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Gram Negative
Diplococci |
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What virulence factors does Gonorrhea possess?
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1. Attaches to mucosal cells via PILI and OPA PROTEIN
2. POR PROTEIN evades destruction by phagolysosome |
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What stimulates the inflammatory response in Gonorrhea?
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Lipooligosaccharides
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How is Gonorrhea transmitted?
Who is at greatest risk for Gonorrhea? |
- Transmitted via direct mucosal contact
- 6-7x higher prevalence in adolescents |
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When do males show symptoms of Gonorrhea?
Females? |
Males: 5-7 days
Females: ~2 weeks |
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How is Gonorrhea treated?
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Single Dose ceftriaxone (3rd generation cephalosporin)
- Spectinomycin for those allergic - Treat or chlamydia too if not ruled out |
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What are the cellular characteristics of Chlamydia?
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Gram Negative
Bacilli Requires living cells tissues for culture |
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What are the 2 forms that Chlamydia exists in?
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1. Elementary Body: infectious form
2. Reticular Body: Non-infectious intracellular form that promotes replication |
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What is the pathology of Chlamydia?
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- Obligate intracellular pathogen
- EB enters cells, replicates are RB - Destroys host cells - NO IMMUNITY |
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What is more common, Chlamydia or Gonorrhea?
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Chlamydia - most commonly reported infectious disease in the US
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What are the usual symptoms of Chlamydia?
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- 75% of women and 50% of men are ASYMPTOMATIC
- lymphogranuloma venereum - same as gonorrhea |
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How is Chlamydia treated?
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Single Dose Azithromycin
or 7 day regiment of doxycycline |
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What is pelvic inflammatroy disease, Ectopic Pregnancy, Fizhugh-Curtis syndrom, and Reiter's syndrome associated with?
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Gonorrhea
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What are the cellular characterisitics of Treponema pallidum (Syphilis)?
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- Spirochete
- Motile |
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How is Syphillis tested for?
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Under darkfield microscopy
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In syphilis, what forms at the primary lesion where spirochetes lodge at entry site?
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- Chancre
- Heals spontaneously within 1-6 weeks |
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What are the stages of a Syphilis infection?
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1. Primary Syphilis: 9-90 days. Seen primary chancre, painless
2. Secondary Syphilis: Occurs 2-8 weeks after chancre. Rash, CONDYLOMATA LATA, CNS disease. 3. Tertiary Syphilis - Gummatous, cardiovascular, neurosyphilis |
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What are the 3 types of tertiary syphilis and their characterisitcs?
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1. Gummatous syphilis: 10-15 years. Gummatous lesions.
2. Cardiovascular Syphilis: 20-30 years. Endarteritis of aortic vasovasorum 3. Neurosyphilis: Meningovascular (5-10yrs). Parenchymatous (20yrs), Tabes Dorsalis (25-35yrs) |
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How is Syphillis treated?
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1. Penicillin G
2. Doxycylcine in allergic patients |
