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19 Cards in this Set

  • Front
  • Back
Picornavirus
ss(+)RNA, non-enveloped
icosahedral capsid

-->enteric replicate better at 37C, acid stabile

Poliovirus
Echovirus
Coxsackie A and B
Enteroviruses

-->respiratory replicate better at 33C and are acid labile
Rhinoviruses
Picornavirus Replication
ss(+)RNA non-enveloped

binding and fusion with ss(+)RNA into genome

ss(+)RNA acts as mRNA and long polypeptide produced, cleaved by encoded proteases

RdRP encoded and replicates template ss(-)RNA to new ss(+)RNA

lysis
Poliovirus Tissue Pathology
Picronavirus> Enterovirus> non-env. ss(+)RNA

replicates in oropharanx
viremia
CNS with replication in motor neurons in the alpha-horn
Poliovirus Serotypes
3 types

vaccine consists of all three
Types of Polio infections
Asymptomatic

Abortive (headache, nausea, vomitting)

Nonparalytic (septic meningitis)

Paralytic (flaccid paralysis)
Post-Paralytic Syndrome
years after initial polio infection

progressive muscle wasting
Cocxsackie A
Picronavirus> Enterovirus> ss(+)RNA, non-enveloped

herpangia (fever, sorethroat)

hand-foot-mouth disease (rash on hands, feet/ ulcers in mouth)

AFFECTS SKIN AND MUCOUS MEMBRANES
Coxsackie B
Picronavirus> Enterovirus> ss(+)RNA non-enveloped

pleurodynia (myalagia, fever, chest pain)

myocarditis
pericarditis

BOTH CAUSE URI, FEBRILE RASH, MENINGITIS
Coxsackie Replication
Picronavirus> Enterovirus >ss(+)RNA
non-enveloped

-->binding and fusion

-->ss(+)RNA acts as mRNA and get long polyprotein

-->encoded protease cleaves

-->replication in cytosol, lysis of cell
Echovirus
Pricronavirus> Enterovirus

ss(+)RNA noneveloped virus

fecal-oral transmission

causes a URI, febrile, meningitis, infantile diarrhea

30+ serotypes
Various Enterovirus Serotypes
Polio= 3 serotypes

Echovirus = 30+ seotypes

Coxsackie= type A and B
Rhinovirus
Picornovirus> Rhinovirus

ss(+)RNA non-enveloped

100+ serotypes

URI, common cold, sinusitis, conjunctival infections

cell rec. = ICAM-1

citric acid kills virus
how to kill Rhinovirus
citric acid

Na+ lauranyl sulfate
Rhinovirus Words
-->Picronavirus

-->URI, common cold

-->100+ serotypes

-->cirtic acid kills it

-->ICAM-1 receptor
Rhinovirus Cell-Receptor
ICAM-1
Calicivirus
Norovirus

(replication same as Picornavirus)

ss(+)RNA

surface spikes
Norovirus Words
cruise-ships

Calicivirus= ss(+)RNA with spikes

watery, non-bloody diarrhea
Reovirus
Rotavirus

dsRNA, 10-11 segments

packages RdRP

common in infants, mainly duodenal infection

CLEARANCE OF VILLI

6 serotypes
Rotavirus Words
-->duodenal villi destruction

-->NSP4 enterotoxin = Ca dep. transepithelial secretion

-->Reovirus= dsRNA, 10 segments with packed RdRP

-->mostly infants

-->6 serotypes