Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
19 Cards in this Set
- Front
- Back
Picornavirus
|
ss(+)RNA, non-enveloped
icosahedral capsid -->enteric replicate better at 37C, acid stabile Poliovirus Echovirus Coxsackie A and B Enteroviruses -->respiratory replicate better at 33C and are acid labile Rhinoviruses |
|
Picornavirus Replication
|
ss(+)RNA non-enveloped
binding and fusion with ss(+)RNA into genome ss(+)RNA acts as mRNA and long polypeptide produced, cleaved by encoded proteases RdRP encoded and replicates template ss(-)RNA to new ss(+)RNA lysis |
|
Poliovirus Tissue Pathology
|
Picronavirus> Enterovirus> non-env. ss(+)RNA
replicates in oropharanx viremia CNS with replication in motor neurons in the alpha-horn |
|
Poliovirus Serotypes
|
3 types
vaccine consists of all three |
|
Types of Polio infections
|
Asymptomatic
Abortive (headache, nausea, vomitting) Nonparalytic (septic meningitis) Paralytic (flaccid paralysis) |
|
Post-Paralytic Syndrome
|
years after initial polio infection
progressive muscle wasting |
|
Cocxsackie A
|
Picronavirus> Enterovirus> ss(+)RNA, non-enveloped
herpangia (fever, sorethroat) hand-foot-mouth disease (rash on hands, feet/ ulcers in mouth) AFFECTS SKIN AND MUCOUS MEMBRANES |
|
Coxsackie B
|
Picronavirus> Enterovirus> ss(+)RNA non-enveloped
pleurodynia (myalagia, fever, chest pain) myocarditis pericarditis BOTH CAUSE URI, FEBRILE RASH, MENINGITIS |
|
Coxsackie Replication
|
Picronavirus> Enterovirus >ss(+)RNA
non-enveloped -->binding and fusion -->ss(+)RNA acts as mRNA and get long polyprotein -->encoded protease cleaves -->replication in cytosol, lysis of cell |
|
Echovirus
|
Pricronavirus> Enterovirus
ss(+)RNA noneveloped virus fecal-oral transmission causes a URI, febrile, meningitis, infantile diarrhea 30+ serotypes |
|
Various Enterovirus Serotypes
|
Polio= 3 serotypes
Echovirus = 30+ seotypes Coxsackie= type A and B |
|
Rhinovirus
|
Picornovirus> Rhinovirus
ss(+)RNA non-enveloped 100+ serotypes URI, common cold, sinusitis, conjunctival infections cell rec. = ICAM-1 citric acid kills virus |
|
how to kill Rhinovirus
|
citric acid
Na+ lauranyl sulfate |
|
Rhinovirus Words
|
-->Picronavirus
-->URI, common cold -->100+ serotypes -->cirtic acid kills it -->ICAM-1 receptor |
|
Rhinovirus Cell-Receptor
|
ICAM-1
|
|
Calicivirus
|
Norovirus
(replication same as Picornavirus) ss(+)RNA surface spikes |
|
Norovirus Words
|
cruise-ships
Calicivirus= ss(+)RNA with spikes watery, non-bloody diarrhea |
|
Reovirus
|
Rotavirus
dsRNA, 10-11 segments packages RdRP common in infants, mainly duodenal infection CLEARANCE OF VILLI 6 serotypes |
|
Rotavirus Words
|
-->duodenal villi destruction
-->NSP4 enterotoxin = Ca dep. transepithelial secretion -->Reovirus= dsRNA, 10 segments with packed RdRP -->mostly infants -->6 serotypes |