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33 Cards in this Set
- Front
- Back
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Influenza A Virus: Classification
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Orthomyxovirus
Enveloped -ssRNA Segmented genome H#N# Subtypes |
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Influenza A Virus: Diagnosis
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Epidimeological info. clinical...
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Influenza A Virus: Pathology/Immunity
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Incubation of several days
Virus shed for 5-7 days ACUTE SELF LIMITED INFECTION innate and adaptive responses UTATIONS THROUGH ANTIGENIC SHIFT AND DRIFT |
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Influenza A Virus: Pathology
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Damage to ciliated epithelia
Risk of bacterial superinfection Hemagglutinin HA binds to sialic acid Neuraminidase NA leaves scialic acid for virus release M2 ion channel aids in uncoating |
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Influenza A Virus: Epidemiology
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Causes Pnademics (spish flu, bird flu, wine flu)
Cuases most epidemics Transmited by respiratory secretions Kills 37000/year in us |
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Influenza A Virus: Disease/symptoms
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Abrupt fever
Myalgia sore throat nonproductive cough general muscle aches malaise may cause bacterial secondary infection (pneumonia, viremia, heart and brain infections) |
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Influenza A Virus: Treatments/Vaccines
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Innactivated vaccine
Attenuated Vaccine (flu mist) Both trivalent Amantadine/Rimantidine inhibits M2, resistance high Relenza/Tamilu inhibit NA |
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Influenza B Virus: Classification
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Orthomyxovirus
Enveloped -ssRNA Segmented genomes NO subtypes |
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Influenza B Virus: Diagnosis
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epidimiological inf
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Influenza B Virus: Pathology/immunity
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Incubation of several days
Virus shed for 5-10 days Acute self limited infection Innate and adaptive repsonse Mutations through antigenic shift and drift |
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Influenza B Virus: Epidemiology
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Infects only humans
Cuases some epidemics Transmited via respiratory secretions |
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Influenza B Virus: Symptoms
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Milder symptoms than influenza A
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Influenza B Virus: Treatment/vaccine
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Vaccines (inactive or attenuated)
Relenza Tamiflu |
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Influenza C Virus: Classification
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Orthomyxovirus
Enveloped -ssRNA Segemented genome |
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Influenza C Virus: Diagnosis
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epidiemiological information
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Influenza C Virus: Common Pathology
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Incubation of several das
virus shed for 5-10 days acute and self limited infection innate and adaptive immune system mutations through antigenic shift/drift |
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Influenza C Virus: Epidimeology
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Infects only humans
Transmitted by respiratory secretions Relatively rare |
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Influenza C Virus: Symptoms/Disease
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Minor respiratory symptoms
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Influenza C Virus: Treatment/vaccine
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No vaccines needed
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Herpes Simplex Virus 1 (HSV1): Classification
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Alpha-herpesvirus
Neurotropic Enveloped dsDNA Gycoprotein spikes |
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Herpes Simplex Virus 1 (HSV1): Diagnosis
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Swab lesion
PCR Viral Culture Rapid tests |
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Herpes Simplex Virus 1 (HSV1): Common Pathology/Immunity
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Glycoproteins bind to cell receptors and mediate fusion
Tegument/capsid deposited within cytoplasm and uses microtubules to mvove to nucleus 3 waves of transcription -immediate early -early -late |
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Herpes Simplex Virus 1 (HSV1): Specific Pathology/Immunity
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Infect mucosal and epidermal cells through breaks in skin
Spreads to sensory neurons Necleocapsid to cell body Viral DNA either replicates or latent Does not integrate Reactivation triggered by stress, UV light, Nerve trauma T Cells critical |
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Herpes Simplex Virus 1 (HSV1): Epidimeology
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Very contagious through oral secretions
Oral sex risk 40% of first genital regions 75% of first/recurrent infectionsasymptomatic 58% of adults infected |
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Herpes Simplex Virus 1 (HSV1): Disease/Symptoms
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Oral/genital lesions (herpes labialis/genitalis)
Encephalitis Kertitis immunocompromised have recurrences in atypical sites |
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Herpes Simplex Virus 1 (HSV1): Treatments
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Acyclovir/valvacyclovir (activated by HSV enzyme thymidine kinase, inhibits viral DNA replication)
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Herpes Simplex Virus 2 (HSV2):
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Alpha herpesvirus
Neurotropic enveloped dsDNA Glycoprotein spikes |
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Herpes Simplex Virus 1 (HSV1): Diagnois
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Swab lesions
PCR Viral culture Rapid test |
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Herpes Simplex Virus 1 (HSV1):Common pathology/immunity
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Glycoproteins bind to cell receptors, mediate fusion
Tegument/capsid deposited within cytoplasm and uses microtubules to move to nucleus 3 waves immediate early, ealy, late |
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Herpes Simplex Virus 1 (HSV1): Spicific pathology
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Infects mucosal and epidermal cells through breaks in skin
Spreads to sensory neurons Nuclocpasid to cell body Viral DNA replicates or is latent Does not integrate Reactivation by fever, stress, uv, nerve trauma T cells for immune response |
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Herpes Simplex Virus 1 (HSV1): Epidemology
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Sexual transmission
Perinatal transmission 60% of first episode genital sores 90% of genital recurrenses 75% of first/recurrent infections asymptomatic 17% of adults infected 4th most common STD |
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Herpes Simplex Virus 1 (HSV1):Disease/Symptoms
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Genital lesions
Increases HIV risk |
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Herpes Simplex Virus 1 (HSV1): Treatment/Vaccination
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Acyclovir/eatacyclovir
Vaccines in development |
