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40 Cards in this Set
- Front
- Back
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Clinical manifestations of Brucellosis?
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flulike symptoms
undulant fevers bone/joint infections CNS infections |
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Forms of anthrax?
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Cutaneous
Gastrointestinal Inhalational |
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Clinical manifestations of Tularemia?
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Ulceroglandular (eschar)
Oculoglandular Glandular Typhoidal Pulmonary Pharyngeal |
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Clinical manifestatsions of Capnocytophaga canimorsus infection?
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fulminant sepsis
disseminated intravascular coagiulation |
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Major animal reservoirs of plague?
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GREAT KAZAKHSTAN GERBIL
Prairie dogs, other rodents |
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Francisella tularensis immune evasion mechanisms?
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-obligately intracellular
-nonimmunogenic LPS -phase variation |
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Brucella spp. virulence factors?
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-Type IV secretion system
-survives inside phagocytes -shuts off immune response via B cell mitogen |
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Francisella tularensis virulence factors?
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30kb pathogenicity island
induces caspase-1 dependent host cell death |
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Clinical manifestations of Pasteurella multocida infections?
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skin/soft tissue infections
osteomyelitis respiratory tract infections |
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Clinical manifestations of Streptobacillus moniliformis infections?
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Rate Bite Fever
fever (duh) migratory polyarthralgias rash on dorsal surface of hands, soles of feet |
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Virulence factors of Pasteurella multocida?
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phage-encoded toxin
constitutively activates G proteins --> mess up signaling induces actin polymerization |
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Reservoir of Pasteurella multocida?
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respiratory flora of birds, cats, dogs
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Reservoir of Capnocytophaga canimorsus?
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mouth flora of dogs and cats
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Reservoir of Streptobacillus moniliformis?
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normal upper respiratory flora of rats
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Reservoir of Francisella tularensis?
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rabbits
free-living amoebae |
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Reservoir of Bacillus anthracis?
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environment
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Special growth needs of F. tularensis?
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cysteine
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Reservoir of Brucella spp?
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cows/bison (B. abortus)
pigs (B. suis) sheep/goats (B. melitensis) dogs (B. canis) |
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How is Brucellosis transmitted?
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-consumption of unpasteurized dairy products
-sometimes infects through mucous membranes/inhalation |
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Transmission of tularemia?
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arthropod vectors
contact w/infected rabbits |
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prophylaxis of Brucellosis?
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pasteurize dairy products
vaccinate goats, sheep, etc. |
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Transmission of C. canimorsus infections?
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animal bites
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Colonial morphology of Bacillus anthracis?
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"ground glass"
nonhemolytic medusa head border tacky consistency may produce capsule in ++CO2 |
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Pathogenicity of B. anthracis?
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basically turns host into culture media
obliterates innate immune system communication: p38, Nalp1 inflammasome overwhelming infection, hemhorrage, necrosis, liver failure antiphagocytic D-glutamate capsule, siderophores, cytolysin |
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Disease course of inhalational anthrax?
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prodrome (malaise, flulike symptoms but no runny nose or headache/body aches)
brief asymptomatic period indicative of immune system collapse all hell breaks loose: hemhorrage, respiratory distress, shock, meningitis, death |
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prophylaxis of Brucellosis?
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pasteurize dairy products
vaccinate goats, sheep, etc. |
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Components of anthrax toxin?
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PA = protective antigen, B subunit
LF = lethal factor (MAPKK cytotoxin) EF = edema toxin (cAMP toxin) ejected into cell upon acidification of endosome. |
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Transmission of C. canimorsus infections?
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animal bites
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How is inhalational anthrax spread?
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only through inhalation of airborne spores.
NO P2P spread! |
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Colonial morphology of Bacillus anthracis?
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"ground glass"
nonhemolytic medusa head border tacky consistency may produce capsule in ++CO2 |
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Tx of anthrax?
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NO BETA LACTAMS! (resistant)
fluoroquinolone/doxy + rif or clindamycin MUST treat during prodrome, treat for 60 days due to spores |
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Pathogenicity of B. anthracis?
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basically turns host into culture media
obliterates innate immune system communication: p38, Nalp1 inflammasome overwhelming infection, hemhorrage, necrosis, liver failure antiphagocytic D-glutamate capsule, siderophores, cytolysin |
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Dx of anthrax?
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x-ray/CT: widened mediastinum
serology: anti-cell wall AB's PCR bacteriophage sensitivity rapid immunochromatographic tests gram stain: large bamboo GPR normal WBC count. |
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Disease course of inhalational anthrax?
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prodrome (malaise, flulike symptoms but no runny nose or headache/body aches)
brief asymptomatic period indicative of immune system collapse all hell breaks loose: hemhorrage, respiratory distress, shock, meningitis, death |
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Which zoonoses activate caspase-1 cell death pathway?
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B. anthracis
F. tularensis |
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Components of anthrax toxin?
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PA = protective antigen, B subunit
LF = lethal factor (MAPKK cytotoxin) EF = edema toxin (cAMP toxin) ejected into cell upon acidification of endosome. |
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How is inhalational anthrax spread?
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only through inhalation of airborne spores.
NO P2P spread! |
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Tx of anthrax?
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NO BETA LACTAMS! (resistant)
fluoroquinolone/doxy + rif or clindamycin MUST treat during prodrome, treat for 60 days due to spores |
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Dx of anthrax?
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x-ray/CT: widened mediastinum
serology: anti-cell wall AB's PCR bacteriophage sensitivity rapid immunochromatographic tests gram stain: large bamboo GPR normal WBC count. |
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Which zoonoses activate caspase-1 cell death pathway?
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B. anthracis
F. tularensis |
