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12 Cards in this Set
- Front
- Back
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What cytokines activate NK cells for innate immunity?
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IL-12
IFN-alpha IFN-beta |
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What is a source of Il-12 to activate NK cells?
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Macrophages which have ingested bacteria
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Once IL-12 activates the NK cell, what can it then do?
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Produces IFN-y which indirectly activates the macrophage itself to increase its metabolism to kill the bacteria.
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What is the direct way that NK cells kill virus infected cells and tumor cells?
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By binding cells that lack MHC, and secreting perforin and granzymes into the cells.
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What is a non-chemical mediated pathway of NK cell killing?
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Fas-FASL interactions
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What antibody isotype is involved in ADCC using NK cells?
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IgG
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How does ADCC work with NK cells?
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IgG coats the virus-infected cell; the Fc-gamma receptor on NK cells binds the IgG and allows the NK cell to kill it.
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If NK cells don't require MHC to allow them to kill cells, what prevents them from killing normal cells in the body?
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The presence of MHC class I on all nucleated cells acts as a ligand for the Inhibitory receptor on NK cells.
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How do NK cells recognize virus-infected cells?
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They are class I MHC negative, so the lack of the inhibitory signal tells the NK cell to go ahead and kill it.
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What are intraepithelial lymphocytes?
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The small population of Tcells with gamma-delta TCRs!
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What is special about gammadelta Intraepithelial lymphocytes (IELs)?
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They can recognize antigen in the ABSENCE of MHC.
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Where are intraepithelial lymphs expressed?
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At mucosal surfaces
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