Micro Winter 30 Lyme Disease

Front 1

what are the 3 spirochetes we are interested in

how can you tell them apart

Back 1

1. Borellia burgdorgeri
2. borellia recurrentis
3. leptospiria interrogans

*distinguished by their spiral and the arrangement of flagella

Front 2

what is the most common tick borne disease in US

Back 2

lyme disease

caused by Borellia burgdorfi

reservoir: small mammel bird,
vector: ixodes tick

NOTIFIABLE

Front 3

is lyme disease notifiable

Back 3

yep- caused by tick bite from ixodes

Front 4

tell me about borrelia burgdorfi

Back 4

gram -
spirochete
visualized w/dark field microscopy

LINEAR chromosome w/linear and circular plasmids

motile

obligate parasite

Front 5

can B burgerdorfi live on its own

Back 5

NOPE, its an obligate parasite

SLOWE grower on agar

Front 6

whats a sequela of lyme infection

Back 6

juvenile RA

Front 7

whre is lyme disease from borrelia burgdorfi common

Back 7

NE US and also around great lakes

Front 8

is borrelia burgdorfi infection more common w/outdoor activity

Back 8

ya, tick bites from ixodes

esp if you live in NE US

Front 9

what co infections can we see with lyme disease- borrelia burgdorfi

Back 9

babesiosis
anaplasmosis
bartonella
mycoplasma
CMV, EBV

Front 10

the white footed mouse transmits what

Back 10

borellia burgdorfi- ixodes

the white tail deer also lets the tick mature

Front 11

what tick transmits borellia burgerdorfi

Back 11

hard body ticks! the ixodes (deer and western black legged)

reservoir is white mouse/deer

Front 12

is there transocvarial passage with ixodes tick that transmitts borelia burgdorfi

how often does this tick feed,

Back 12

nope

they feed ONCE, complete feed takes 3-6 days, decrease risk of transmission

Front 13

what does it mean if a momma tick is infected with a bug and the baby ticks come out infective

Back 13

transovarial passage, this means that the first time the larva feed thay can pass disease

Front 14

inorder to transmit lyme disease what must the tick do

Back 14

M+

ONLY the nymph and adult stages are infective (bc there is NO tranovarial infectino)

MUST feed for 2 days to transmit lyme disease

Front 15

when is it most likely to get lyme disease from ixodes, tick

Back 15

late spring summer. its when they are out an about

recall no transovirial so mst be nymph or adult to infect. needs to feed for 2 days

Front 16

what stage is the most common way for lyme disease to be transmitted (B burgdorfi)

Back 16

nymph, super small hard to see and so hard to remove- must feed 48 hours

Front 17

tell me about the OSP A nad C for virulence of B burggdorfi

Back 17

plasma endoded outer susface protein

A- binds bacteria to tick mudgut
C- invasion of bacteria into human skin

Front 18

what are hte 3 stages of lyme disease B burgdorfi

Back 18

1. early: local, tx w.AB, multiplication of bacteria at bite site (OSM-C) bulls eye rash
2. disseminated: joints, csf, liver, spleen, heart infected through lymph/blood.
3. late/persistent: years later. lyme arthritis in large joints. neuropathy w.congnifive impairments, spinal radicular pain

Front 19

when do you see a bulls eye rash

Back 19

inlyme disease, early infection. called erythema migrans

Front 20

is there respiratory/GI manifestaions fo early stages of lyme disease (B burgdorfi)

Back 20

NO

Front 21

what ist eh disseminatedpart of lyme disease

Back 21

lymph, blood carries to JOINTS, CSF, spleen, liver, heart

arthralgia, athritis, TMJ

can get bells palsy, painful radiculopathy

heart disease

Front 22

tell me about late lyme disease

Back 22

occurs MONTHS or YEARS later

persistant arthritis in few large joints

decreased cognition, spinal radicular pain

Front 23

when might you do serology for disseminated lyme disease

Back 23

travel to endemic area

risk for tick exposeure

sx: arthralgia, (TMJ) bulls eye rash

Front 24

what is the 1 and 2 step for lyme serology

Back 24

1. ELISA to detect anti BORELLIA AB

2. Confirm with Western BLOT elisa for B Burgdorfi

Front 25

does lyme disease require a 2 step serology for dx

Back 25

yep

1. anti borellia AB w/eliza

2. then use WB to detect anti B burgerdorfi

Front 26

whats lyme disease tx w/

Back 26

doxy, easy to kill adn control in early stage

Front 27

what is Jarisch Herxheimer response

Back 27

seen wih some lyme disease cases in like 24 hrs

rapid killing so release of toxic products. increased circulating cytokines

you get: restless, apprehensive and then get rigors. you increased temp respiration and BP then it all decreases

Front 28

if you were in fected w/lyme disease this am and now you have LOTS of cytokines released whats it called. what sx does it lead to

Back 28

jarisch herxheimer response

restless, apprehensive, rigors, increased in temp/BP/RR/HR ---> decrease!

5% mortality

Front 29

whats the vaccine for lyme disease

Back 29

taken off market!

Front 30

if you get bit with tick in endemic area whats the % you will get lyme disease

Back 30

3.2

Front 31

how do you prevent lyme disease

Back 31

avoid ticks, long sleve, tuck long pants into socks, wear light colored clothes, DEET

Front 32

do you twist a tik out

Back 32

nope, pull straight out, dont squeeze body

Front 33

wjats borelli STARI

vector:

Back 33

southern tick associated rash illness

Vector: ambylomma americanum (lone star tick) bites us! hard body tick like oxodes BUT this one bites us in larva, nymph and adult stage (ixodes is just nymph and adult)

Front 34

whats ambylomma americanum

Back 34

lone star tick, passes southern tick assciated rash illness

**the larvea, nymph and adult ALL bite human

Front 35

if you get that erythema migrans bulls eye and other lyme like sx but the elisa and WB come out neg what can it be

Back 35

STARI from lone star (ambylomma americanus)

fat as a tick!