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40 Cards in this Set

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Who was responsible for the magic bullet? and the 606 tries to find a cure for syphillus?
Erlich.
What was the name of the cure?
Salvarsan
What is the active ingredient in sulfanilamide
prontosil
who discovered Prontosil?
Domagk...in the 1900's
What is prontosil?
Analog of PABA
What is PABA?
folic acid is a competitive inhibitor, and plays a crucial role in metabolism. Take it when you're pregnant
What is Hydrochloride?
Anti-Tuberculosis remedy
What is used for UTI infections?
Nalidixic Acid
What is salvarsan?
It is an arsenic compound...the start of chemotherapy
What are the four synthetic drugs that we covered?
Salvarsan, Prontosil, Isoniazid, and Nalidixic Acid
what do sulfa drugs do?
SD's make PABA inactive. Micro-organisms synthesize folic acid. We have to eat folic acid. Sulfa's inhibit folic acid...but since we don't make it in our bodies, it works on micro-organisms. Sulfa drugs compete with PABA in folic acid.
What kind of an infection is amphotericin B?
systemic
what do we get ampicillin from?
penicillin chrys.
What is the type of antibio that we use on small children?
amoxacillin
What are the four antibiotics used for G + organisms?
Penicillin, Erythromycin, Cephalothin, and Bacitracin
Penny, Eryca, Cephie, and Baci (becky)
What is bacitracin used for?
SKIN
what type of antibiotics do most doctors and dentists use?
Gram +
What are two examples of G - antibiotics?
Gentamicin, and Zyvox(linezolid, 2000)
Waht is Gentamicin known for?
nephro-toxocities (in the liver)
name 5 Broad Spectrum (affects both G+ and G- )antibiotics
Amp-icillin
Bactim
Chloramphenicol
Piper-icillin
Tetracycline
What is unizue about Chloramphenicol?
bad side affects, but it works against typhoid fever
what causes Typhoid Fever?
Salmonella Typhii
What Ab is used for ear infections in children?
Bactrim
What is the mode of action of a protozoa in antibiotics?
to inhibit cell wall synthesis,
damage cell wall
inhibit's protein synthesis
inhibit's nucleic acid synthesis
What does AAPMC stand for?
Antibiotic-Associated-Pseudomembrane-Colitis
What are two protozoan Ab's?
Chloroquine, and metronidazole
Name a beta lactamase
Dicloxicillin
What is special about beta lactamases?
they are very tough to beat.
explain zoning.
the bigger the zone is around that organism,the more suceptible that organism is to that anti-microbial.
what is the "r factor?"
a plasmid. Codes for multiple anti-biotic resistance
What are two tests used for Antibiotic Sensitivity testing?
Kirby Bauer disk plate assay
MIC determination-minimum inhibitory concentration: take antimic and dillute it, and add organism and incubate to see concentration
What are five synthetic antivirals?
Amantadine,
Acyclovir,
Ribavirin,
Rifampin,
and Zidovudine (AZT = Retrovir
What are hte four ingredients in HART?
Zamoduvodine, Lamoduvovine, Duvodine, and Retronovir
What type of organism is Bacitracin used against?
G +
What type of organism is Cephalothin used against?
G +
What is the source of Cephalothin?
Cephlosporium acremonium
What is the source of Erythromycin?
Streptomyces erythreus
Where are a lot of antibiotics grown inthe soil?
Abbott, Libertyville.
What is the drug, Augmentin used for?
pheumoniz, bronchitis, UTI's, Cellulitis
What organisms does Rocephin kill?
SA, EC, Strepto P, KP, HI