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26 Cards in this Set
- Front
- Back
Subgingivial nasty pathogens include...
P gingivalis B forythus T denticola |
all 3
|
|
mast cells releasing histamine is characteristic of what type of response?
|
immediate response
|
|
recognition of molecules like n-formylmethionyl and production of anaphylatoxins like c3a/c5a recruiting neutrophils is what type of response?
|
acute
|
|
what type of bact invade epith/ct?
G+ or G- Cocci, rods, filaments or spirochetes? |
all
|
|
Which of these organisms invade host tissue cells?
A actintomyce P gingivalis F nucleatum Treponema denticola |
ALL
|
|
Bacteria often cause cells to become (rounder/more rigid) thru degrading ____molecules, such as occludin or ICAM1
|
rounder
adhesion |
|
Aa/Pg/Fn all can induce the cell to _____, but actually Pg actually intiially____ it.
|
apoptosis
inhibits it |
|
Epith cells can produce _____to bind calcium, killing Pg bacteria.
|
calprotectin
|
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Ging epith cells produce ______which are assoc w/ epith structure and restric replication/destruction
|
beta defensin
|
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f nucleatum triggers production of IL8 which is a ____factor and classified as a _____
|
chemotactic cytokine
|
|
Pg and Aa can produce _____which destroys the ECM, so the body can't ______ and its cells cant______
|
collagenase
mount immune response migrate |
|
Aa causes increased release of IL's 1, 6, 8, TNF, and prostaglandin E
|
True
|
|
Chemotactic agents for recruitment are an..
IL__ Leukotriene____ and C___ |
8
B4 5a |
|
3 examples of _____ are
LPS iC3b Abs |
opsonizers
|
|
PRR's can be _____such as receptor kinase, TLRs or can be ____such as nod-like, or ____such as mannin binding lectin
|
membrane
cytoplasmic secreted |
|
TLRs lead to activation of transcription factors such as_____, which induces expression of cytokines, chemokines and other inflammatory factors
|
NF-kB
|
|
match these
IL1 TNF IL6 with these osteoclast activating Bone remodeling Osteoclast activating |
IL1/TNF are oclast activate
IL6 is bone remodel |
|
IL1 and TNFa are primarily produced by _____whereas TNFb is produced by ____.
|
activated macrophages
CD4Th1 cells |
|
____hormone has a dampening effect on the TF ______.
|
estrogen
NF-kB |
|
IL1/TNFa stimulate endoth cells to express ______s, which recruits more______.
|
selectins
leukocytes |
|
Matrix _____ are a family of ____dependent endopetidases, that degrade ECM parts such as ____, _____, and _____.
|
metalloproteinases
zinc collagen gelatin elastin |
|
PGs are derived from ____acid.
|
arachidonic
|
|
COX1 or COX 2 is normally expressed in most tissues
|
COX1
|
|
COX 1 or 2 is not susually expressed but is induced by cytokines or inflammation
|
cox2
|
|
formation of PGs relies on activity of what 2 enzymes
|
cyclooxygenase
peroxidase |
|
Prostaglandin E2 (PGE2) has one very important action which is a potent____and works with other mediators such as _____to promote_____.
|
vasodilator
histamine edema |