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26 Cards in this Set

  • Front
  • Back
Subgingivial nasty pathogens include...
P gingivalis
B forythus
T denticola
all 3
mast cells releasing histamine is characteristic of what type of response?
immediate response
recognition of molecules like n-formylmethionyl and production of anaphylatoxins like c3a/c5a recruiting neutrophils is what type of response?
acute
what type of bact invade epith/ct?
G+ or G-
Cocci, rods, filaments or spirochetes?
all
Which of these organisms invade host tissue cells?
A actintomyce
P gingivalis
F nucleatum
Treponema denticola
ALL
Bacteria often cause cells to become (rounder/more rigid) thru degrading ____molecules, such as occludin or ICAM1
rounder
adhesion
Aa/Pg/Fn all can induce the cell to _____, but actually Pg actually intiially____ it.
apoptosis
inhibits it
Epith cells can produce _____to bind calcium, killing Pg bacteria.
calprotectin
Ging epith cells produce ______which are assoc w/ epith structure and restric replication/destruction
beta defensin
f nucleatum triggers production of IL8 which is a ____factor and classified as a _____
chemotactic cytokine
Pg and Aa can produce _____which destroys the ECM, so the body can't ______ and its cells cant______
collagenase
mount immune response
migrate
Aa causes increased release of IL's 1, 6, 8, TNF, and prostaglandin E
True
Chemotactic agents for recruitment are an..
IL__
Leukotriene____
and C___
8
B4
5a
3 examples of _____ are
LPS
iC3b
Abs
opsonizers
PRR's can be _____such as receptor kinase, TLRs or can be ____such as nod-like, or ____such as mannin binding lectin
membrane
cytoplasmic
secreted
TLRs lead to activation of transcription factors such as_____, which induces expression of cytokines, chemokines and other inflammatory factors
NF-kB
match these
IL1
TNF
IL6
with these
osteoclast activating
Bone remodeling
Osteoclast activating
IL1/TNF are oclast activate
IL6 is bone remodel
IL1 and TNFa are primarily produced by _____whereas TNFb is produced by ____.
activated macrophages
CD4Th1 cells
____hormone has a dampening effect on the TF ______.
estrogen
NF-kB
IL1/TNFa stimulate endoth cells to express ______s, which recruits more______.
selectins
leukocytes
Matrix _____ are a family of ____dependent endopetidases, that degrade ECM parts such as ____, _____, and _____.
metalloproteinases
zinc
collagen
gelatin
elastin
PGs are derived from ____acid.
arachidonic
COX1 or COX 2 is normally expressed in most tissues
COX1
COX 1 or 2 is not susually expressed but is induced by cytokines or inflammation
cox2
formation of PGs relies on activity of what 2 enzymes
cyclooxygenase
peroxidase
Prostaglandin E2 (PGE2) has one very important action which is a potent____and works with other mediators such as _____to promote_____.
vasodilator
histamine
edema