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19 Cards in this Set
- Front
- Back
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What is the purpose of Interferons?
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They interfere w/ viral replication in infected cells
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What are the 3 major actions of INFalpha and Beta?
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1. Activate PKR expression
2. 2'5' oligo-Asynthetase 3. Mx Proteins |
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What is the path of PKR expression? What does this?
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IFNa/b do this, PKR recognizes dsRNA, and phosphorylates into eIF2-alpha, which inhibits translation
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What is the path of 2'5'oligo-A synthetase, what does this?
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IFNa/b, it induces linkage of oligonuc'tides in irregular order, which make RNase-L enzyme, which degrades mRNA
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What is the path of Mx proteins? what does this?
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IFN-a/b, which uses de-phosphorylates GTP, and inhibits Tx, viral assembly
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What are the 2 ways NK cells kill (direct/indirect)?
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They bind and kill cells or they release IFN-gamma to recruit Macrophage
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What are the 2 MECHANISMS thru which NK cells kill directly?
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1. Fas-L-Fas: polymerizes Fas to activate apoptosis
2. Secrete Perforin-granzyme: Perf. makes hole, Granzyme activates enzymes for apoptosis |
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What are 2 diseases of PHAGOCYTE DYSFUNCTION
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Chronicgranulamatous disease, and Chediak-Higashi syndrome
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What is Chronic Granulamatous disease?
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Defect in NADPH oxidase (phagocyte dysfunciton disease)
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What is Chediak Higashi syndrome?
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Defect in protein involved in the Phagosome-Lysosome Fusion (phagocyte dysfunction disease)
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What is an example of Adhesion dysfunction?
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Defect in Beta-2chain of leukocyte Integrins LFA and CR3
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What is an example of Chemotaxis disfunction?
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Lazy Leukocyte Syndrome - defect in C5a, defect in cytoskeleton
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What are the 4 Complement system defects?
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Nod- receptor, NLRP3, MyD88, IRAK-4
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What are the 2 Pyogenic bacteria-sensing deficiency disorders, what category are they in?
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MyD88 and IRAK-4, complement disorders
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What is the order of Phagocytes to arrive at an infection?
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Neutrophils then Monocytes
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What receptors are involved in Neutrophil binding to Epithelium?
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ICAM1 and ICAM2 (of epith) bind to CR3 and LFA1 of neutrophil, also CXCL8 of epith binds to neurophil (CXCL8-R)
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What happens if neutrophils/monocytes are ineffective in stoping infection?What mediator is involved in this?
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Acute Phase response to generate more cells and receptors - IL6
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What does IL-6 do? what is it a part of?
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Acute phase response, it acts on liver/bone marrow to produce more cells
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What role does the liver play in acute phase repsonse?
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It generates c-reactive protein PHOSPHOCOLINE to activate compliment or MBL
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