Micro- Intracellular Bacteria

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Name bacteria that causes these clinical syndromes and their s/s, tx, distribution.
Orroya fever and verruga peruana

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Bartonella

Orroya fever and Veruana:
Invade erythrocytes and endothelial cells causing anemia, swelling, vasoooculsion, and thrombosis. Usually orroya fever (anemia) followed 2-8wks later by eruptive verruga pertuana. Tx: doxy, chloramphenical, blood transfusion

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Trench fever
Cat scratch disease
Bacillary angiomatosis-peliosis

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Bartonella

Trench Fever: transmission human body louse with s/s that influenzae like(myalgias, chills, fever, h/a, and bone pain). Tx: doxy or macro (theme crosss cell membrane)

Cat Scratch disease: cat or flea bits (1/3 of domestic cats). Infects endothelial cells w/ sx of lympahdenopathy and papule (contact site). Tx; Doxy or macro

Bacillary angiomatosis-peliosis: Cats & human body louse that infect immuno-compromised pts.
Infects endothelium of capillaries & prodcues bacillary angiomatosis (enlarged cranbery-like papules that may become ulcerated). Peliosis hepatica lesions are cytics blood-filled spaces lined by fibromyxoid matrix (bacteria). Tx: Macro

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Typhus

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Rickettsia prowazeckii - rash starting on trunk & migrates to ext. Common in crowded places and wars (thus vaccination of military recruits). Tx: Doxy

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Brill's disease

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Latent infection reemergence of R. prowazekii

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Endemic typhus

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Rickettsia typhi - rat flea feces transmission that is prevalent in warm climates. Tx: Doxy or chloramphenical

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Scrub typhus

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Oreitia - similar to endemic typhus, but no rash. Caused by chigger bite and common in Asia Pacific are.

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Spotted fever

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Rickettsia rickettsia - RMSF (mid-atlantic states): macular rash begins in extremities and spreads to trunk w/ some petechiae. Transmission through tick bite. Tx: doxy

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Ehrlichiae

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Target cells are phagocytes and multiply in phagosomes as opposed to cytosol.
Human moncytotrophic Ehrlichiosis (Ehrlichia) deer tick. Likes macrophages and moncytes.
Human anaplasmosis: Transmission thourgh same Ixode tick as Lyme disease. Infects neuts and less severe than HME.Look for inclusion bodies in neuts. Tx: doxy

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Q Fever

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Influenza-like illness caused by coxiella burneti. Common infection of ruminants and transmission through inhalations of aerosols. Survives in phagolysosome. Low mortality, but serious illness. Tx: doxy or quinolones/

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Typhus

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Trunk to extermity rash. Tx: doxycycline

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Spotted fever

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RMSF: Midatlantic and OK/Ark/Mizz

Rash spread from extremities to trunk.