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24 Cards in this Set

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what are some viruses that cause pharyngitis?
adenovirus, coronavirus, rhinovirus, cocksackie, epstein-barr, influenza, parainfluenza, enterovirus, cytomegalovirus, HIV, resp syncytial virus
charac of adenovirus
ds DNA
non-enveloped (lytic)
icosahedral
~47 serotypes
what is the significance of the large amt of serotypes?
hard to vaccinate
increase antigenicity
what property does a non-enveloped virus have that increases pathogenicity?
generally more resistant in environment (fomites)
structure and receptor of adenovirus
fiber spikes- hemagglutinating, attach to receptor (Ig to block attachment)
receptor: CAR; Ig superfamily on tight jxns of epithelium
reservoir, transmission adenovirus
man
aerosol, contact, fecal-oral, mucosa, FOMITES, pools
pathogenisis of adenovirus
mucoepithelial cells: reps, GI, conjunctiva, cornea
lytic, persistent and latent infections
clinical disease caused by adenovirus
URI in kids
acute resp distress and pneumonia
adults usually mild pharyngitis
conjunctivitis
gastroenteritis
entry of adenovirus
upper resp and eye; can become systemic
what is the diff between subgenus and serotype (as pertains to adenovirus)
subgenus (fxnal group)- based on oncogenicity in animals
serotype (Ig dep neutralization)- based on antigenic epitopes of fibers
lab diagnosis of adenovirus
detect Ag: rapid; detect Ag in aspirates or washings
isolate virus: aspirates, throat swabs, feces
serology: retrospective analysis; C' fixation
cytopathic effect of adenovirus
infected cells are rounded; dark basophilic inclusions in nuclei (viral proteins)
monolayer of cells is cleared by lysis
tx and prevention of adenovirus infections
no tx; self-limiting
vaccine for Adult Resp Distress Synd (recruits): live attenuated 4,7,21 in eneterically coated capsules(+ CTLs),
what is important about the prep of the adenocirus vaccine?
enterically coated capsules- uncoats (limited replication) in GI to stim IgA prod; GI IgA can protect resp tract mucosa
what are 2 types of coxsackie viruses, where are they found, and what presentation are they assoc with?
A- oropharnyx; vesicular lesions
B-pneumonia, bronchitis, UR flu
transmission of cocksackie?
fecal-oral and airborne
charac of cocksackie
non-enveloped
+sense RNA
icosahedral
cytolytic
self-limiting
in Picornaviridae family (enterovirus-polio)
what is herpangina?
vesicular lesions in the throat caused by cocksackie
-white papules, red base and posterior palate
S/S cocksackie infection
sudden fever
sore throat
headache
dysphagia
malaise
herpangina
epstein-barr virus aka:
human herpes virus 4: HHV 4
what does HH4 infect? cause?
only infects oro and nasopharynx epithelial cells and B cells with CD21 (C3dR)
causes mononucleosis
charac of epstein barr virus
in epithelial cells: permissive and lytic
in B cells: episomal (around B cell genome) and latent
clinical disease caused by EBV
most infections asx (asx shedders)
infectious mononucleosis- fever, lymphadenopathy, sore throat (TONSILLAR EXUDATE), apparent LYMPHOCYTOSIS
describe the throat in EBV pharyngitis; what does it resemble?
red throat
white tonsillar exudate
resembles GABHS tonsillitis