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35 Cards in this Set
- Front
- Back
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Bordetella discovered by _____ and _____ in _____.
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Bordet and Gangov in 1906
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Bordetella is similar to _____ but does not need _____.
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similar to hemophilus but does not need x/v factors
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3 species of Bordetella
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B. pertussis
B. para-pertussis B. bronchiseptica |
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most serious of the Bordatellas
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B. pertussis - highly contagious, mostly in children, 90% non-immunized
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___% of B. pertussis victims suffer permanent CNS damage
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17%
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___% of B. pertussis victims suffer mental retardation.
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27.5%
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Do children normally recover who develop coma resulting from B. pertussis?
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No, they die.
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What does LPF in B. pertussis pathogenicity stand for?
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lymphocytosis promoting factor
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What does HSF in B. pertussis pathogenicity stand for?
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histamine sensitizing factor
(promotes coughing) |
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To diagnose B. pertussis, it grows on ______.
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BG media (Bordet and Gangov)
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therapy for B. pertussis
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erythromycin (safest)
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prevention of B. pertussis
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a component of DPT, a killed phase I organism
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The mode of transmission of B. pertussis is____.
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whooping cough
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Bordetella is gram - or +
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gram negative coccobacillus (rod), small in size, non-motile (except in B. bronchiseptica), non spore forming
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the organism Bordetella forms by pairs or chains?
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by pairs - end to end
(short chains in liquid cultures) |
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The disease pertussis is also called____.
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whooping cough
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Chinese called whooping cough ______.
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"cough of 100 days"
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___% of whooping cough cases occur when?
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1st year of life
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____% of non-immunized against pertussis who are exposed, contract the disease.
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90%
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Is pertussis well-controlled in the U.S.?
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No. It is the least well controlled bacterial vaccine-preventable disease.
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B. pertussis produces a endotoxin or exotoxin?
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Both.
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In a Bordetella culture, incubation takes ___hrs at __degrees
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72 hrs at 37 deg C
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How do the toxins form in the epithelium of the resp tract?
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colonization (smooth, pearly)
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What agar is pertussis cultured on?
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potato-blood-glycerol
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whooping cough treatment
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1st (catarrhal) stage - antitoxin
2nd (paroxysmal) stage - erythromycin |
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5 toxins of pertussis
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1. Lipopolysaccharide (endotoxin)
2. Heat labile (unstable) protein - may be change to toxoid 3. Pertussis toxin - most harmful 4. Metabolic alterations (IAP) 5. LPF - change into toxoid, neutralized by antitoxin |
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T or F. Phase I of B. pertussis is capsulated, smooth wet pearly colonies and is the most contagious.
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True. Phase IV however is uncapsulated, dry rough colonies
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3 stages of B. pertussis
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1st - catarrhal
2nd - paroxysmal 3rd - convalescent |
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Which stage of pertussis is known as the spasmodic stage?
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2nd - paroxysmal
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incubation of the 1st (catarrhal) stage of pertussis
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7-14 days
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The 2nd (paroxysmal) stage of pertussis lasts ___ weeks.
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1-6 weeks
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Which stage is the most serious of pertussis?
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2nd (paroxysmal) stage. thick mucous, vomitting, convulsions, spasms, sudden onset CNS damage, coma, death
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The 3rd (convalescent) stage lasts ____ weeks.
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2-3 weeks
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T or F. The 3rd stage of pertussis is the most severe?
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False. It is a gradual decline in severity, secondary, 10% bacterial, hemophilus, strep pneum
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Which stage of pertussis involves whoop and pharyngitis primarily?
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1st (catarrhal) stage. It also includes ropy discharge, slight conjuctivitis, and sneezing
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