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28 Cards in this Set
- Front
- Back
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Primary response |
first response to an antigen |
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Secondary response |
If body encounters antigen again Stronger |
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T cells mature in |
Thymus Made in thymes |
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What do lymphatic vessels do?
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Carry lymph |
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Secondary Lymphoid Organs |
Sites where lymphocytes gather to contact antigens |
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Primary lymphoid organs |
bone, and thymus |
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Variable vs. constant region on antibody |
Constant remains the same Variable is "where the business happens" |
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Antibodies have a basic ______ shape Two copies include |
"Y" shape Heavy chain (4) and light chain (2) |
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Neutralization |
prevents toxins and viruses from binding |
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Opsonization |
enhancement of phagocytosis |
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Complement system activation |
classical pathway |
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immobilization and prevention of adherence |
binding to bacterial flagella or pili interferes |
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aggregation |
2 arms of antigen bind separate antigens |
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antibody-dependent cellular cytotoxicity |
targets cell for destruction by natural killer (NK) cells |
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IgM |
First class produced during primary response 10-14 days until significant amount |
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IgG can be |
transported across placenta to fetus's bloodstream |
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Maternal IgG does what? |
Protects fetus and newborn |
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IgG is found in |
colostrum (first breast milk) absorbed by newborn's intestinal tract |
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IgE |
allergic reactions barely detectable in normal blood |
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Hypersensitivity allergic reactions |
can be life threatening |
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Clonal Selection Theory |
able to recognize functionally limitless variety of antigens Each cell only recognizes and responds to a single epitope |
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Immature lymphocytes |
lack fully developed antigenspecific receptors |
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Naive lymphocytes |
have receptors; have not yet encountered appropriate antigen |
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Activated lymphocytes |
have bound antigen and received confirmation, are able to proliferate |
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Effector lymphocytes |
are descendants of activated lymphocytes ex. plasma cells, T cells |
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Memory lymphocytes |
long lived descendants of activated lymphocytes; responsible for rapid secondary response if antigen encountered again |
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How long does it take for substantial antibody accumulation? |
10-14 days |
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Exogenous antigens are produced by |
Antigenpresenting cells (dendritic cells, B cells, macrophages) |
