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30 Cards in this Set
- Front
- Back
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Where r class I MHC found? any exception?
Where r class II MHC found? |
all cells type except RBC
adaptive defense: T, B cells, macrophages, APC, dentritic Immune system cells |
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a)Most abondant type of WBC? it produces what particular particles?
b)Which fights parasitic worms? |
a)Neutrophils, defensins
b)Eosinophils |
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What is opsonization?
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coating of foreign by complement and AB
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NK cells r called... becoz...
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NK cells r called "pit bulls" becoz they police the body(kills cancer & virus))
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sign of inflammatory response
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redness
heat swelling pain |
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explain
Diapedesis Margination |
Diapedesis: leukocytes pass trough capillary walls
Margination: Leukocytes cling to capillary walls |
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complement kills by which method?
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lysis, MAC forms a hole in cell's membranes & induces Ca++ influx into target
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In complements:
Classical pathway involves... however Alternative pathway involves... |
a) AB +AG complex, then C proteins
b) microorganism cell wall polisaccharide, then factors B,D,P & C proteins |
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What is the difference between innate & Adaptive defenses?
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Innate is always ready and able to react
Adaptive: take time, must meet by an initial exposure the foreign substance, specific |
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Which are the strongest antigens?
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Proteins
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What r the 5 Ig types?
Whic pentamers, dimers, monomers other names for AB? which part of B or plasma cells r they? |
MADGE
Immunoglobulins gamma globulin part |
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a)What is the 1rst AB class to be released in blood by plasma cells
b) most abundant in plasma c)only one that crosses placenta, passive immunity d)primary mucus, outside surface e)act as a B cell receptor f)troublemaker, bcoz of allergies g) readily fix complement proteins h) potent agglutination AB |
a) IgM
b) IgG c) IgG d) IgA e) IgD f) IgE g) IgM & IgG h) IgM |
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Helper Tc arise from
Cytotoxic T cells arise from |
a) CD4
b)CD8 |
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Class I MHC r recognized by...
Class II MHC r recognized by... |
by CD8 T cells
by CD4 T cells |
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Which cell type slows/stops., activity of T & B cells
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Suppressor T cells
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What is needed for B cell activation?
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Antigen, Cytokine, helper Tc
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How does antibody work?
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Have a PLAN
Preci Lys(complement) Agglu Neutra |
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Explain MHC restriction
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Class I MHC, CD8, cytotoxic cell, body cell
Class II MHC, CD4, Helper T cells, macrophages |
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Granulocytes leukocytes r...
Agranulocytes leukocytes r... |
neutro, most numerous, anti-bacteria
baso, not phagocytic, least numerous, IgE eosino. longest LS, anti-worms monocytes, macro. : LS=months, |
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Leukocytes, monocytes arise from... stem cell
Lymphocytes arise from... stem cell |
myeloid
lymphoid |
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IL-1?
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causes fever, promotes inflammation
secreted & activated by Macrophages stimulates T & B cells |
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IL-2?
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secreted by T helpers cells
stimulates T & B cells T cell growth factor |
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IL-3?
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leukocytes & mast cells
basophils |
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IL-4?
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secreted by T helper cells
causes plasma cells to secrete + IgE co-stimulated activated B-cells |
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IL-5?
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secreted by T helper cells & mast cells
attracts eosinophils causes plasma cells to secrete + IgA |
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IL-6?
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differentiation of B cells to plasma cells
stimulates T cells stimulates liver to secrete mannose-binding protein(target bact. with man. capsules) |
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IL-7?
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stimulates B cells,
Inc macrophages activity |
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IL-8?
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angiogenesis
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IL-9?
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stimulates myeloid to produce blood cells
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IL-10? similar to T s cells
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stops/reduces immune response
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