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9 Cards in this Set
- Front
- Back
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What is a retrovirus?
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Retroviruses have the enzyme reverse transcriptase, which synthesizes DNA from an RNA template, a reverse transcription.
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What is so unusual about the reverse transcriptase?
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The reverse transcriptase enzyme can replicate a double strand of DNA from single strand of RNA.
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What is the receptor for HIV attachment to cells, and what cells have this receptor?
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T cell receptor in CD4 or Th cells.
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Discuss the transmission of HIV.
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access to bloodstream
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When do overt symptoms of AIDS appear?
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appear 8 to 10 years of infection or when CD4 cell counts drops to less than 200 cell/mm
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How does the genome of HIV persist in certain human cells?
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The genome of HIV persists in certain human cells because the reverse transcriptase makes a DNA copy that integrates to become part of the cell genome.
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What actually kills AIDS pts?
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CD4 cells are gradually reduced to zero, preventing the formation of memory cells and expanded cell populations of any immune cells, so opportunistic infections cannot be surmounted by the immune system.
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What is the relationship between AIDS and Kaposi's sarcoma?
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There is a high incidence of Kaposi's sarcoma in AIDS pts due to reactivation of the human herpes virus 8.
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How can the spread of AIDS be reduced?
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avoid anal sex, do not have multiple sex partners, avoid recapping needles, use condoms, practice abstinence or one faithful sex partner, and use PPE for healthcare workers
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