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34 Cards in this Set

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DOC for P.jiroveci infection
TMP-SMX
opportunistic pulmonary infection caused by reactivation of latent infection in immunocompromised hosts
P. jiroveci
P.jiroveci attaches to what cells via what structures
type I pnomocytes via fibronectin and glycoproteins
multinucleated giant cells on Tzank smear
HSV
painful ulcers are generally found with what infections?
viral infections (HSV) or chancroid
structure and genetics of HSV
ds linear DNA w/ icosahedral neucleocapsid and lipoprotein envelope
DOC for HSV
acyclovir
the cause of vaginitis is usually determined by what
KOH wet mount for yeast or protozoa, gram stain for Gardnerella or Mobiluncus (clue cells)
vaginal discharge characteristics- white, yellow/grey, or foul smelling
white-candidiasis, yellow- Trichomonas vaginalis, foul smelling- bacterial vaginosis (gardnerella/ mobiluncus)
morphological characteristics of candida
yeast with pseudohyphae, true hyphae, and/or chlamydospores
diagnostic feature of C. albicans
chlamydospores
drugs used for the Tx of vaginal candidiasis
clotrimazole, miconazole, nystatin, or oral fluconazole
white plaques adherent to tongue and buccal mucosa, sometimes with angular cheilitis is indicative of what organism
oral candidiasis
organism which may cause "diaper rash"
cutaneous candidiasis
systemic candidiasis most often occurs in what pt populations
pts in the ICU, pts with severe granulocytopenia, organ or stem cell transplant recipients
characteristics of primary HIV infection
fever, malaise, lymphadenopathy, truncal maculopapular rash, 'mononucleosis-like symptoms'
HIV transmembrane proteins
gp120(cap) and gp41(stem)
HIV capsid protein
p24
describe viral attachment and uncoating in HIV infection of T cells
gp120 binds to CD4 molecules, gp120 then undergoes a conformational change to bind a coreceptor (CXCR4 or CCR5), conformational change in gp41 leads to fusion of the cellular and viral membranes and entry
what is the genetic unit of HIV
ssRNA
when should prophylaxis be started for P.jiroveci and MAC in AIDS pts?
P. jiroveci at CD4 count below 200 and MAC at CD4 counts below 50
cause of Kaposi sarcoma
HSV-8
disease associated with cats
toxoplasmosis (T. gondii)
morphological characteristics of T. gondii
banana shaped tachyzoites in proliferative infection, cyst bradyzoites in asymptomatic infection
at what CD4 level might you begin to suspect Toxoplasmosis
<200
DOC for Toxoplasmosis
sulfadiazine + pyrimethamine w/ or w/out leucovorin
ring enhancement seen on MRI of brain leasion is usually associated with what organisms?
T.gondii or nocardia asteroides?
hystological appearance of CMV infection
cytomegalic (giant) cells, cells w/ intranuclear inclusion w/ surrounding 'halo' ("owl's eye")
CMV family and genetics
herpes virus, dsDNA w/ lipoprotein envelope
most common post-transplant infection
CMV
DOC for CMV
ganciclovir
what are the ToRCHeS-List organisms
Toxoplasmosis, Rubella, Cytomegalovirus, Herpes, HIV-1, HBV, Syphilis, Listeria
what organisms cause infectious mononeucleosis?
EBV and CMV
Sx of CMV retinitis
floaters, flashes, blurred vision, decreased visual acuity, and scotomata (blind spots)