Micro - Antibiotics

Front 1

Name the five beta-lactam antibiotic classes

Back 1

1. Penicillin
2. Cephalosporins
3. Carbapenems
4. Monobactams
5. Beta-Lactamase Inhibitors

Front 2

How do beta-lactam antibiotics work?

Back 2

Disrupt peptidoglycan cross-linkinking in bacterial cell wall. Structural analog.

Front 3

What three ways do bacteria resist beta-lactam antibiotics?

Back 3

1. Beta-lactamase production
2. Altered Penicillin-Binding Proteins
3. Impenetrable to antibiotic, or efflux pumps

Front 4

Which penicillins are used for gram-positive organisms?

Back 4

PCN-G and V. If resistant withi penicillinase, Dicloxacillin

Front 5

Which penicillins are used for gram-negative organisms?

Back 5

Aminopenicillins: Ampicillin, Amoxacillin

Front 6

What common penicillin includes an inhibitor?

Back 6

PCN/Beta-Lactamase Inhibitor: Amoxacillin-Clavulanate (Augmentin)

Front 7

What are the six antibiotic drug classes that block bacterial protein synthesis?

Back 7

1. Linezolid
2. Aminoglycosides
3. Tetracyclines
4. Clindamycin
5. Streptogrammins
6. Macrolides

Front 8

You've converted your PPD, but don't have active TB. What drug do you use first?

Back 8

Isoniazid (INH)

Front 9

What drugs don't work against MTB?

Back 9

Beta lactams (MTB has no peptidoglycan)

Front 10

What gives MRSA its drug resistance?

Back 10

MRSA's beta lactam resistance comes from the mecA gene, encoding Altered Penicillin Binding Proteins

Front 11

How does Vancomycin work?

Back 11

Class: Glycopeptide Antibiotic
Mech: Prevents cell wall synthesis
Use: MRSA, enterococcus, C. difficile

Front 12

What are the MRSA drugs?

Back 12

Vancomycin, daptomycin, linezolid