Micro 7

Front 1

____ and ____ inhibit viral uncoating

Back 1

Amantadine, Rimantadine

Front 2

Viral polymerase inhibitors
• Directly bind to viral NA polymerase → no viral NA synthesis
eg. _____™ → acts on ____

Back 2

Foscarnet

HIV, Herpes Simplex Virus

Front 3

Nucleoside analogues (Agents similar in structure to nucleic acid bases)
eg. ____ (guanine analogue) → acts on _____
eg. ____ (thymine analogue) → acts on ____

Back 3

Acyclovir acts on Herpes Simplex Virus
Azidothymidine acts on HIV

Front 4

Protease Inhibitors: Protease = an enzyme encoded by HIV which is needed to
complete the synthesis of viral structural proteins
⇒ can be inhibited by various agents (eg. ____™, ____™) to prevent final assembly of new viruses

Back 4

Ritonavir and Saquinavir

Front 5

Neuraminidase Inhibitors: Neuraminidase = enzyme encoded by influenza virus which is needed by virus to be released from host cell
eg.___ ™, _____™

Back 5

Tamiflu and Relenza

Front 6

Interferon (INF): Small molecules produced by virus-infected cells that diffuse out and stimulate neighboring cells to make ___ and block viral replication, etc

Back 6

anti-viral proteins

Front 7

___ is an infectious agent consisting only of protein
(Proteinaceous infectious particle)

Back 7

Prion

Front 8

Prions Produce slowly developing ____ degenerative diseases characterized by___-like masses in the brain →“Spongiform encephalopathies” (Kuru, Creutzfeldt-Jakob, BSE, Chronic Wasting Disease, etc)

Back 8

neurological

sponge

Front 9

Prions are abnormal variants (____) of normal proteins (___) found mostly in neurons

Back 9

PrPSC

PrPC

Front 10

____ are virus-encoded proteins produced during viral replication are toxic to the host cell

Back 10

Virokines