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10 Cards in this Set

  • Front
  • Back
____ and ____ inhibit viral uncoating
Amantadine, Rimantadine
Viral polymerase inhibitors
• Directly bind to viral NA polymerase → no viral NA synthesis
eg. _____™ → acts on ____
Foscarnet

HIV, Herpes Simplex Virus
Nucleoside analogues (Agents similar in structure to nucleic acid bases)
eg. ____ (guanine analogue) → acts on _____
eg. ____ (thymine analogue) → acts on ____
Acyclovir acts on Herpes Simplex Virus
Azidothymidine acts on HIV
Protease Inhibitors: Protease = an enzyme encoded by HIV which is needed to
complete the synthesis of viral structural proteins
⇒ can be inhibited by various agents (eg. ____™, ____™) to prevent final assembly of new viruses
Ritonavir and Saquinavir
Neuraminidase Inhibitors: Neuraminidase = enzyme encoded by influenza virus which is needed by virus to be released from host cell
eg.___ ™, _____™
Tamiflu and Relenza
Interferon (INF): Small molecules produced by virus-infected cells that diffuse out and stimulate neighboring cells to make ___ and block viral replication, etc
anti-viral proteins
___ is an infectious agent consisting only of protein
(Proteinaceous infectious particle)
Prion
Prions Produce slowly developing ____ degenerative diseases characterized by___-like masses in the brain →“Spongiform encephalopathies” (Kuru, Creutzfeldt-Jakob, BSE, Chronic Wasting Disease, etc)
neurological

sponge
Prions are abnormal variants (____) of normal proteins (___) found mostly in neurons
PrPSC

PrPC
____ are virus-encoded proteins produced during viral replication are toxic to the host cell
Virokines