Micro 63 - 66

Front 1

Zoonotic Definition

Back 1

An INFECTIOUS disease o fLower Animals that may be Transmitted to human.. Transmission may be direct, contact, animal vectors & or by formites

Front 2

What is the zoonotic source for
1. Measles
2. Tuberculosis
3. Small pox
4. Influenza (2)
5. Pertussis (2)
6. Faliciparum Malaria (2)

Back 2

1. Cattle (rinderprest)
2. Catitle
3. Cattle (coxpox)
4. Pigs, Ducks
5. Pigs, Dogs
6. Birds (Chickens & Ducks)

Front 3

Name the Catogory "A" Bio Warfare/Terror Agents
1. Zoonotic (4)
2. Non-Zoonotic (2)

Back 3

1. Bacillus antracis, Yersina pestis, Francisiella tularensis & Viral haemorrhagic fevers
2. Clostridium botulinum toxin & variola major

Front 4

Name the Category "B" Bio Warfare/Terror Agents that are
1. Zoonotic (3)
2. Non-Zoonotic (3)

Back 4

1. Brucella species, Burkoholderia mallei & Coxieall burnetti
2. Clostridium perfringens Epsilon toxin, Ricinus communis toxin & Staph aureus enterotoxin B

Front 5

Most common zoonotic infection in the USA

Back 5

1. Lyme disease (Boreilla burgdoferi)

Front 6

Rickettsiae. Bame the 2 in the
1. Thyphus group (2)
2. Spotted Fever, Group A (2)
3. Spotted Fever, Group B (2)
4. Spotted Fever, Group C (2)
5. Scrub Thyphus

Back 6

1. prowazekii & thyphus
A. rickettsi & siberica
B. conori & perkeri
C. akari & australis

Front 7

What causes
1. Cat Scratch disease
2. Q Fever
3. Human Erlichosis
4. Special quality for each

Back 7

1. Rochakimaea henselae (& growin in artifical cultures)
2. Coxiella burnetii (& Survives in dust)
3. Erlicha chaffeensis (& invades Human WBC)

Front 8

Rickettsial Diseases
1. Common feature (3)

Back 8

1. STEADY high fever, Severe Retoorbital headache 7 rash

Front 9

Define the following exanthems
1. Macule
2. Papule
3. Vescile

Back 9

1. Discolorred spot, darker than surrounding skin. LEAKAGE of blood into epithelium
2. ELEVATED spot, d/t INFLAMMATION.
3. Elevated small BLISTER. Surrounded by INFLAMED skin & loaded w/ INFECTIOUS material

Front 10

Define the following exanthems
1. Vesicle
2. Pustule
3. Crust

Back 10

1. Elevated small BLISTER. Surrounded by INFLAMED skin & loaded w/ INFECTIOUS material
2. Same as Vesicle, but filled with PUS (normally infectious)
3. DRIED, partially healed pustule. Infections organism (semi dormant)

Front 11

Rickettsia prowazekii
0. Causes
1. Primary Reservoie
2. Transmission via (2)
3, Secondary Reservoir & related vectors (2)

Back 11

1. Man
2. Body louse → Pediculus corporis/humanis & Crab louse → Pthirus pubis
3. Sheep, Cattle & Goats → Ambyloma (ticks)
4. Wild flying squirrel → Lice & Flies

Front 12

Pediculus corporis/humanis
1. Vector type
2. Perferred tempertatuere? Results in?
3. Attracted by (2)
4. Avoids parts of body
5. Prefers what clothing
6. Insect population in infected huma

Back 12

1. Human body louse (ectroparasite of Man)
2. 29⁰c -30⁰c. Leaves host once has fever
3. Odor & Own feces
4. Moisture
5. ROUGH surfaces
6. 10-20 instects

Front 13

Effects of R. prowazekii on Pediculus sp. vector
1. Louse infection (4)
2. Mean survival rate

Back 13

1.Midgut → Multiply in epithelial cells→Tissue destroyed & Lysed → Reelaces in to faeces
2. 10 days after infection

Front 14

R. prowazekii → Epidemic Thyphus
1. Incubation
2. Rash
3. Symptoms (2)
4. Complications (3)
5. Inoculation can also occur

Back 14

1. 7-14 dats afer bite
2. Centrifugal maculopapular rash
3. Rickettsial headache & STEADY high fever
4. Myocarditis, vascular collapse & CNS dysfunction
5. By swatting the Louse into your skin

Front 15

Epdimeci Thyphus
1. Diagnosis
2. Therapy (2)
3. Reach detectable levels

Back 15

1. Serological (retrospective)
2. Straight away, based on history & presentation
3. 6-8 weeks post infection

Front 16

Epidemic thyphus.. Prognosis
1. ↑ Fatality rate
2. Untreated fatality rate is %
3. ↑ Risk of mortality

Back 16

1. Delay of correct therapy in 2nd week of illness
2. 25%
3. Manutrition, Stress or Secondary Infection

Front 17

Rickettsia rickettsii
0. Causes
1. Region
Tick responsible
2. Western states
3. Eastern States
4. Southwest
5. Name the 3 reservoirs

Back 17

0. RMSF (Rocky Mountain Spotted Fever)
1. Appalachian Mts (Gerogia, Oklahoma, Arkansas & Text)
2. Dermacentor adnersonii → Wood Tick
3. Dermacentor variabilis → Dog Tick
4. Ambylomma americnaum → Lone Star Tick
5. Dogs, Wild Rodents & Tick itself (trans-ovarial)

Front 18

RMSF
1. Incubation
2. Rash Type
3. Rash appears
4. Symptoms (5)
5. Complications (6)

Back 18

1. 2-6days
2. CentriPEDAL, Maculopapular, starting at palms & soles
3. 2nd or 3rd day
4. Rickettsial FEVER, Headache, Toxicity, Mental Confusion & Myalgia
5. DIC, Thrombocytopenia, Encephalitis, Vascular Collapse, Renal or Heart Faiulre

Front 19

RMSF
1. Diagnosis
2. Serology
3. Treatment
4. Contraindicated

Back 19

1. History & Symptoms
2. Retrospective
3. Straight away (Teracycline & Chloramphenicol)
4. SULFONAMIDES

Front 20

Coxiella burnetti
1. causes
2. Multiplies in
3. Prefers
4. Unique characteristic
5. Reservoir animals (2)

Back 20

1. Q Fever
2. Phagolysome
3. Low pH
4. Dry dust @ 40°C
5. Cattle Sheep & Goats

Front 21

Coxiella burnetii
1. Primary Exposure via
2. Secondary route (2)
3. Most human infections are
4. Geo Epi

Back 21

1. Inhalation of Dust
2. Ingestion of contaminated Meat or Dairy
3. In apparent symptoms (walking pneumoniae)
4. Hiking in the desert. Arid (dry) South West

Front 22

Coxiella burnetii
1. Incubation period
2. Rash
3. Symptoms (4)
4. Complications are (3)

Back 22

1. 7-21 dAYS
2. ABSENT
3. Fever, Chills, "usual" headache, Mild Dry Persistent Cough & Patchy interstitial pneumoniae
4. Endocarditis, Encephalitis & VERY RARE fatalities

Front 23

Coxiella burnetii
1. Diagnosis
2. Treatment (2)

Back 23

1. Retrospective
2. Supportive care, although most will resolve retrospectively

Front 24

Erlichosis canis & chafeensis
0. Goegraphy
1. Resembles
2. Causes
3 Transmitted by
4. Symptoms (2)
5. Severe cases (3)
6. Complications (3)

Back 24

0. Appalachian region
1. RMSF
2. Human Granulocytic Ehrlichiosis
3. Brown Dog Tick
4. Fever & GI abnormalities
5. Cough, Diarrhea & Lymphadenopathy
6. Respiratory & Renal Insufficiency & CNS abnormalities

Front 25

Anaplasma phagocytophilum
1. Causes what disease
2. Vector
3. In Host, targets (2)
4. Infection leads to
5. Geography

Back 25

1. Human Granulocytic Ehrlichiosis
2. Ticks
3. Neutrophils & Macrophages
4. Compromised immune system
5. Great lakes & COASTLINE of North East

Front 26

Psittacosis
0. Other name
1. Caused by
2. Reservoir
3. Main Symptom
4. Bacteria shed via (2)
5. Unique, sheddings can?

Back 26

0. Parrot Fever
1. Chlamydophila psattaci
2. Pet Birds
3. SEVERE pneumoniae
4. Feces & Nasal Discharges (Both in Bird)
5. Remain infectious for several months

Front 27

Cat scratch disease
1. Caused by (2)
2. 3-10 days later
3. 2-3 weeks later
4. Persistant for
5. Couse

Back 27

1. Rochalimaea (Bartonella) henselae 90% & Afipa felis
2. Papule/Pustule appears at site of scratch, then heals spontaneously
3. Regional lympadenopathy (HEAD, NECK & AXILLA)
4. 2-4 months
5. Self Limitng

Front 28

Rochalimae (bartonella) henselae
1. Also causes
2. Infections observed in
3. Symptoms
4. Other site

Back 28

1. Bacillary Angiomatosis
2.HIV patients
3. "Cranberry nodules" , multiple subcutaneous red papule.
4. Visceral

Front 29

Bacillus anthracis
1. Type of Bacteria
2. Reservoir
3. Spread by
4. In order for transmission, requires
5. On culture (3)

Back 29

1. Gram POSITVE rod
2. Hoofed & Grazing Animals
3. Grass
4. Death of organism
5. Long chain, with endospores on vegetative cells

Front 30

Bacillus anthracis
1. Type of bacteria
2. Pathogen
3. On culture
4. Spore? Motile? Hemolytic?
5. Type of capsuel

Back 30

1 Large, Strong Gram +ve
2. Facultative Anaerobe
3. Rods in Chains
4. Heat resistant Endospore, No & No
5. Glutamyl polypeptide

Front 31

Bacillus anthracis
1. Name the three virulence factors & roles

Back 31

1. Lethal factor → Tissue Necrosis
2. Edema Factor → Infiltration & Tissue Sweeling. Enhances distribution of Lethal Factor
3. Protective antigen → Carries the TWO factors (separately) across Cell membrane

Front 32

B. antracis
1. Name THREE manifestations & symptoms

Back 32

1. Cutaneous → Molst common, least fatal
2. Gastrointestinal → Rare in humans, high mortality. Most common in Animals
3. Pulmonary→ Highest mortality

Front 33

Cutaneous Anthrax
1. Primary infection as
2. Progresses to
3. Ends
4. Other symptoms (3_
5. Incubation

Back 33

1. Papule
2. Vesicular Stage
3. ESCHAR (necrotic ulcer)
4. Edema, Redness & Necrosis w/o Ulcer
5. 1-12 days

Front 34

Cutaneous Anthrax
1. Diagnosis (3)
2. Blood Culture
3. Biopsy for Immunochemistry if

Back 34

1. Gram stain, PCR or Culture→VESCIULAR fluid, EXUDAGE or ESCHAR material
2. Retropsective
3. If taking antimicrobials

Front 35

Gastrointestinal Anthrax
1. Symptoms (3)
2. Followed by (2)
3. Other sites (3)
4. Develops after
5. Incubation
6. Fatality

Back 35

1. Abdominal Distress, Bloody Vomiting & Diarrhea
2. Fever & Septecemia
3. Oropharyngeal Ulcerations w/ Cervical adenopathy & Fever
4. Ingestion of poorly cooked meat
5.1-7days
6. 25-60%

Front 36

Inhalation Antrax
1. Initial
2. Followed by (2)
3. Complications (2)
4. Incubation
5. Fatality w/ AB treatment
6. W/O

Back 36

1. Flu-like prodrome symptoms
2. Hypoxia & Dyspnea
3. Meningitis (50%) & Rinorrhea
4. 1-7 days (rare up to 42)
5. 97%
6. 75%

Front 37

Inhalation Antrax Diagnosis
1. Chrest X-ray (4)
2. Immunochemistry with
3. Fluid for (3)

Back 37

1. Wiidened MEDIASTINUM, Pleural effusions, Infilitrates & Pulmonary CONGESTION
2. Affected tissue biopsy & Pleural flud cell block
3. Gram stain, PCR & Culture

Front 38

Name the Brucella species related to
1. Cattle
2. Goats
3. Swine
Name the gram negative rods related to
4. Rodents
5. Rabbits
6. Cats, Dogs & Horses
7. Cattle & Horses

Back 38

1. B. abortus
2. B. melitensis
3. B. suis
4. Yersina pestis
5. Francisiella tularensis
6. Pasteurella multicoda
7. Burkholderia mallei

Front 39

B. spcies
1. Bacteria type
2. Pathogen type
3. Spore, Motie, Capsule
4. Unique feature
5. Nutritionally fastiduous (3)

Back 39

1. Gram negative Cocco-bacilli
2. Strict Aerobe (Facultative)
3. No, No, & Small Capsule
4. 2 chromosomes of unequal size, both needed for survival
5. Complex media, Capneic & Slow Growing

Front 40

Brucella soecies
1. In reservoirs
2. Patients normally (2)
3. Transmission via (4)
4. Organism killed by

Back 40

1. Venereal disease of Farm Animals
2. Butchers or Vets
3. Skin breaks, Mucous membranes, aerosols & dairy products
4. Pasteurization

Front 41

1. Brucella abortus reservoir
2. Brucella melitensis?
3. Brucella suis

Back 41

1. Cattle
2. Goats
3. Swine

Front 42

Brucella sp. Pathogenesis
1. Three steps
2. Only control
3. Failure of control leads (3 Steps)

Back 42

Penetrates Skins/Mucous Membranes → Carried to Lymphatics by PMS → MULTIPLY in PMNs
2. T Cell response
3. Bacterial Multiplication w./in RES → Waves of bacteria released → Reccuremnt Bacteremia

Front 43

Brucellosis
1. Incubation
2. Onset of symptoms
3. Present normally in
4. What may perist for months → Years
5. May present with (2)

Back 43

1. 7 → 21 days
2. Drencking Sweat w/ High Fever
3. Afternoon or Evening
4. Nocturnal Fever
5. Arthritis, Orchitis or HEPATOMEGALY

Front 44

Brucellosis
1. Definitive diagnosis (2)?
2. Specimen (4)
3. Special consideration for B. abortus (cattle)
4. Incubation

Back 44

1. Isolation & Culture
2. LYMPH node, Blood, Bone Marrow & Liver
3. Incubate in C02, then use blood agar
4. 2-4 weeks

Front 45

Brucellosis
1. Therapy
2. Issue
3. Treatment muse be
4. Relapses occur

Back 45

1. Chemotherapy
2. Slow results
3. Prolonged
4. up to 3 months

Front 46

Francisiella tularensis
1. Bacteria
2. Pathogen
3. Spore, Motile, Capsule
4. Fastiduous requires
5. Agar
6. Growth time on Agar

Back 46

1. Gram -ve Coccobacillus
2. Facultatitve
3. No
4. SULFYHYDRYL compounds
5. Cysteine-Glucose Blood agar (aerobic)
6. 2-10 days

Front 47

Francisiella tularensis
1. Reservoir (4)
2. Vectors (3)
3. Geography
4. Seasonality

Back 47

1. RABBITS, squirrels, muskrats & deer
2. Deer Flies, Ticks: Dermacentor sp. & Ixiodes sp.
3. North America, Canada & Mexico
4. Late Spring

Front 48

Francisiella tularensis
1. Entry via (3)? Which has highest mortality
2. Minimum infectios dose
3. Bactermic spread → (3)
4. If injected, what develops
5. Recovers confers
6. Patient History

Back 48

1. Inhalation (MOST severe) or Injection (LEAST)
2. <100 cells
3. Infects RES → Granuloma formation
4. Ulcer at injection site
5. Long lasting story
6. Random story involving rabbbits

Front 49

Francisiella tularensis
1. Incubation
2. Onset (3)
3. If Injection
4. Ingestion
5. Inhalation
6. All 3 progress to

Back 49

1. 2-5 days
2. ACUTE fever: Fever, Chills & Mailaise
3. Ulcero-Glandular formation
4. Thypodial
5. Pneumoniae (greatest mortality)
6. Systemic Infection

Front 50

Francisiella tularensis
1. Diagnosis
Pasturella multicoda
2. Diagnosis
3. Difference in symptoms

Back 50

1. Fluroscent Anti-body along with careful history
2. Culture for apirated pus
3. DOES NOT become systemic

Front 51

Pasteurella multicoda
1. Type of bacteria
2. Pathogen
3. Ferments
4.Positive
5. Agar
6. Reservoir
7. Transmission
8. Symptoms (3)

Back 51

1. Gram -ve coccobacillus
2. Facultative
3. Carbohydrates
4. Oxidase positive
5. Enriched blood agar
6. Cats & Dogs
7. Bite or Scratch
8. Diffuse Cellulitis w/ Clear Border at Site of Infection

Front 52

Burkholderia mallei
1. Disease
2. Contracted from (3)
3. Endemic in (5)
4. Morle likely to cause
B. pseudomallei
5. Disease
6. Vehicle
7. Reservoir (6)
8. Endemic in
9. Example
10 More likely to cause

Back 52

1. Glanders (a vet disease)
2. Horse, Donkeys & Mules
3. Asia, Middle East, Africa, Central & South America
4. Acute Local Infeciton
5. Meliodosis (Whitmore's disease)
6. Strangant Fresh water
7. Sheep, Cattle, Pigs, Dogs, Cats & Humans
8. South East Asia (V'NAM)
9. HELICPOTER
10 .Pulmonary Infection

Front 53

Both Burkholderia
1. Four basic from of the disease

Back 53

1. Acute Local→ Ulcer can spread to Lymphatics
2. Pulmonary
3. In immunocompromised, Acute Septicemia → Highest fatality rate
4. Chronic → Visceral damage w/ multiple abcesses

Front 54

Burkoholderia that causes & more like to take what form
1. Glanders
2. Meliodosis

Back 54

1. mallei (local)
2. pseudomallei (pulmonary

Front 55

Glanders & Meliodosis
1. Pulmonary difficult to distinguish vs.
2. Local
3. Isolate bacteria from (3)
4. Chronic infections may remain dormant for (2)
5. Complication (2)
6. Septecemia Fatality w/ treatment
7. w/o

Back 55

1. TB
2. Many other infections
3. Blood Sputum, Urine, Skin lesions sources
4. 10 to 20 yrs
5. HIV & Diabetes
6. 35-60&
7. 95%

Front 56

Yersinia pestis
0. Caused
1. Bacteria
2. Member of
3. 4 characteristics of this group
4. Grows readily on
5. Present in virulent strains

Back 56

0. Black Plague
1. Gram negative
2. Enterobacteriacae
3. Gram -ve non spore forming rod, Oxidase negative, Facultative & Glucose Fermented
4. MaConkey agar
5. Rich polysacchardie capsue

Front 57

Y. pestis
1. Reservoir
2. Type of infection in reservoir
3. Meta-Stable balance =
4. Main vector
5. Flea contracts Yersina when
6. Multiples in (2)
7. Starving flea, when taking next meal
8. Infection in Flea →

Back 57

1. Small Rodents: RATS, voles, Ground hogs & Squirrels
2. Lymphohematogenous (endemic in rodent population)
3. Requries host to grow, but kills host too
4. Xenopsillia cheopsis (Rat flea)
5. Takes blood meal
6. Proventriculs→Block fleas GIT
7. Regurgitates infectious material
8. DEATH

Front 58

Y. pestis
1. Primary Exposure
2. Organisms Spreads to
3. What happens here (3)
4. Spread continue via → (4)
5. Pulmonary infection can be spread via

Back 58

1. Flea bite
2. Lymph Noedes
3. High Temp → Virulence Factor Formation, Rapdi Multiplication, & LN → BUBO (pianful)
4. Bacteriam → Liver, Spleen, Lungs & (sometimes) Meninges
5. Respiratory dropletns (Pneumonic Plague)

Front 59

Yersini pestis
1. Favored LNs (2)
2. Bubonic Incubation
3. Bubonic Acute starge (6)
4. Pneumoninc Incubation
5. Pneumoninc Acute Stage Symptoms (3)

Back 59

1. Inguinal & Axillary
2. 4-7 dayts
3. Swollen, Painful LNs, ↑ Feverm Pooling of Blood & MACROhemmorhages in Face & Extremeties
4. 18-36hrs
5. Violent & Fulminating Pneunmonia. FATAL

Front 60

Y. pestis & HIV ADIS
1. People who survived the plague
2. Heterozygous for mutation
3. Homozygous for mutation
3. He

Back 60

1. Mutation in CCR5
2. ↑ Resistance to HIV
3. Immune to HIV →

Front 61

Y. pestis
Bubonic diagnosis
1. Sample
2. Diagnosis
Pneumonic
3. Sample
4. Diagnosis

Back 61

1. Lymph node aspirate or Blood sample
2. Fluroscent AB diagnosis
3. Sputum
4. Fluorescent AB

Front 62

Transmission via
1. B. recurentis
2. B. burgdorferi
3. Leptospira interrogans

Back 62

1. Louse or Tick borne
2. Ixodes ticks
3. Direct contact or water borne tranmission

Front 63

Borellia recurentis/ Tick borne relapsing fever
1. Louse maintained in
2. Tick maintained in

Back 63

1. Human population
2. Rodent reservoir

Front 64

Borrelia
1. Bacteria
2. Outer Membrane Proteins encoded by? Giving? →
3. Grown on
4. Seen on (2)
5. Diagnosis during

Back 64

1. Gram -ve Spirocherrs, thick & long
2. 4-9 Plasmids, ↑ Anitgenic Variability
3. Barbour-Stoenner-Kelly Medium
4. Microscopy * Fluorescent Microscopy
5. ACute phaase (3-4) days

Front 65

Boreullia recurentis
1. Disease
2. Onset
3. Incubation
4. Invasion of (4)
5. Initial Attack lasts
6. Further symptoms
7. Diagnosis

Back 65

1. Relapsing fever
2. Abrupt Prodrome
3. 3-4 days
4. Spleen, Liver, Kidney, Eyes &/or Brain
5. 3-7 dayts
6. Series of up to 4 cycles, each shorter & less severe
7. Blood smear during Acute phase 3-7 days

Front 66

Lyme disease
1. Most common
2. Reservoir (2)
3. Geo
4. East coast vector
5. West coast Vector
6. Seasonal incidence
7. By

Back 66

1. Zoonotic disease
2. Eastern White-Tail Deer & White-Footed Deer Mouse
3. New England & northeast europe
4. Ixodes dammini
5. Ixodes pacificus
6. Summer
7. NYMPH

Front 67

Borellia sp
1. In tick vector (3 steps)
2. When tick feeds (6 steps)

Back 67

1. Borellia sp→ adheres to epthelial cells of Tick GUT → Quasidormant state
2. Feeding → Mircoorgnaimsims exposed to higher temperatures → Activates them→ Multiply→ Penetrate Slvary Glands →Injected into skin of host

Front 68

Ixodes sp.
1. Season: Egg to Adult
2. When most infectious

Back 68

Winter: Eggs dormant →Spring/Summer Larvae hatch→ Early Fall: Become NYmphs after vertebrate meal → Winter: Nymphs dormant →Spring/Summer : Require another blood meal to become Adult→Summer/Fall: Adult lays eggs
2. The second SRPING/SUMMER

Front 69

1. Ticks are removed via (3)
2. Why

Back 69

1. Tick tool, Burning or Iodine
2. Don't want to squirt disease into host

Front 70

Borrelia burgdoferi. Decribe the time & what is happening
0. Incubation period
1. Stage 1
2. Stage 2
Latent Infection
3. Stage 3

Back 70

27-33 day: Organism multiplies in Skin
1. 4 weeks: Localized infection → Erythema migrans
2. 1 week - 6monints: Disseminated infection → Secondaty ANNULAR skin lesions
L: Organims in protected niches
3. 6 months - 30 years: Acrodermatitis chronicna atrophicans

Front 71

If Boreilla burgdoferi, stragiht into blood
1. Dissemination of Organisms

Back 71

1. Meningitis, Caridits, Musculoskeleton pain & Eye Abnormalities

Front 72

Chronic symptoms of B. burgodorferi
1. Intermittent
2. Chronic (3)
3. Chronic severe

Back 72

Intermittent chronic arthritis
2. Chroninc encephalopathy, ploy neuropathy & Leukoencephalitis
3. Chronic cardiomyopathy

Front 73

B. burgorferi
1. First stage? Time?
2. Oter symptoms (4)
3. Second Stage Symptoms (3)
4. thrid Stage

Back 73

1. Erythema chronicum Migrans "target lesion" @ 3- 14 days
2. Red/Brown purple lesions at Earlobes, Nipples, Scrotum & Exteremties
3. Arthritis (Knee), pain in bursa, tendons & muscle.
4. ACA (Acrodermititis Chronicum Atrophicans) & Discoloration of Skn

Front 74

B. burgodorferi
1. Analgous to

Back 74

1. Syphillus

Front 75

B. burgodorferi
1. During Early stage can be seen in
2. Later stage

Back 75

1. Blood smear
2. Serology unreliable

Front 76

Mode of Transmission & Clinical aspects for the following
1. Lyme Disease (1 & 2)
2. Relapsing fever (2 & 1)
3. Syphillus (2 & 3)
4. Leptospirosis (1 & 3)

Back 76

Front 77

Leptospirosis
1. Animal
2. Shed
3. Transmission between animals via
4. Exposure (2)
5. Organisms enter via (2)
6. Multiply in
7. Seed in (4)

Back 77

1. Kidney in Rodents
2. Urine
3. Drinking water with urine in it
4. Occupational (fly fisher) or Recreational (drinking water from river)
5. Abrasions in skin or Mucous membrane
6. Blood
7. Seed liver, Kidney, Lungs &/or meninges

Front 78

Leptispora interrogans
1. Bacteria
2. Differentiate vs. other
3. Motile, Spore, Capsule
4. Sensitive to (3)
5. Survives how long? in?
6. Enters susceptible host via

Back 78

1. Tight gram-ve SPIROCHETE, think & long
2. Curved into HOOK
3. Motile, no, no
4. Heat, Drying & Most chemicals
5. 1-2 weeks in Slightly Alkaline Ground water/Soil
6. Penetrating Skin/Mucus Membrane

Front 79

Leptospira interrogans
1. Incubation
2. Early symptoms
3. Later symptoms
4. Course
5. Diagnosis

Back 79

1. 8-12 days
2. Flu0like plus PAIN in THIGHS, CALVES & ABDOMEN
3. Weill's Diseae: Jaundice, Renal Dysfuntion & SEVERE HEMORRHAGC Manifestations
4. HIGH mortality rate
5. Serology: Macro & Micro agglutinnation

Front 80

For the following Hemorrhagic Viruses, name the Family, Genus, Disease, Natural Vector & Geo
1. Ebola
2. Marburg
3. Lassa.
4. New world Arenaviridaie
5. Crimean Conog Hemorrhage Fever
6. Rift Valley Fever
7. Hemm. Fever w/ Renal Syndrome
8. Dengue
9. Yellow Fever
10. Omsk Hemm. Fever
11 Kyansur Forest

Back 80

Front 81

Flavivurs
1. Family
2. Genus
3. Genome
4. Class
5. All are? Except
6. All serologically related to

Back 81

1. Flaviviridae
2. Flavivirus
3. ss+ RNA
4. Class IV
5. ARBOviruses
6. Cross Reacting Bodies

Front 82

Name 4 flaviviruses that produce hemmorhagic fever

Back 82

1. Dengue, Yellow Fever, Omsk Hemm. Fever & Kyansur Forest Dz

Front 83

Falvivirus
1. Pathogenesis
2. Infect
3. Damge cells
4. Tissure destruction via
5. Shock syndrome due

Back 83

1.Macrophages
2. Cell damage by cytokine storm
3. Tissue destruciton by T cells
4. Virus-AB complex enters monocytes via FC
5. AB ehnahces infection
6. Increased production of cytokines
7. Severe, illness, shock & hemmorrhagese

Front 84

Dengue Fever
1. Symtpms (3)
2. Hemorrhagic Shock syndrome
3. Vector
4. reservoir
5. Region (5)
6. Key for dengue

Back 84

1. Fever, Rash & Hemorrhagic Shock Syndrome
2. Severe illness, shock, hemmorhage & 10% mortality
3. Mosqutioes
4. Unknown
5. India, SE Asia, Pacific, South America & Caribbean
6. Normal a 1st & a 2nd infection

Front 85

Yellow Fever
1. Reservoir
2. Vector
3.Symptoms (2)

Back 85

1. Monkey
2. Aedes Ageytpi
3. Hemorrhagic fever w/ Jaundice

Front 86

Arena Virus
1. Family
2. Genus
3. Genome
4. Baltimore
5. Unique
6. Cause H.F. ?

Back 86

1. Arenaviridae
2. Areanavirus
3. ss - RNA, 2 segments
4. Class V
5. Host ribosome in virus particle
6. Lass Virus, Macuvirus, Juninvirus, Guantovirus

Front 87

Which arenavirus is located in
1. Argentina
2. Bolivia
3. Sierre leone
4. Venezuale
5. Highest mortalily
6. Reservoid of Bush RAT (Mastomys natelnsis)
7. Bush MICE (Callomys) (2)
8. Cane (zygodontomys bervicauda) & Cotton Rats (Sigmoid alstoni)

Back 87

1. Juninvirus
2. Machupovirus
3. Lass fever
4. Guantovirus (highest nortality)
6. Lass Fever
7. Machu & Junin
8. Guanarito

Front 88

Bunyaviruses
1. Family
2. Genra
3. Genome
4. Baltimore
5. Name THREE. H.F. viruses

Back 88

1. Bunyaviridae
2. Bunyavirus, Hantavirus, & Niarovirus
3. ss - RAN, 3 segments (S, M & L)
4. Group V
5. Nairo: Crimean Congo H.F, Phleb:Rift Valley Fever
Hanta: Korean H.F. (w. Renal Syndrome)

Front 89

Bunyaviruses
1. Reservoir in (3)
2. Pathogenesis

Back 89

1. Mice, Rats & Ticks
2. Plasma & RBC leak through Vascular Epithelium

Front 90

Korean H. F.
1. Genus
2. Symptoms (2)
3.Reservoir
4. Geo (3)
5. In South West USA had

Back 90

1. Hantavirus
2. H.F. w/ Renal Syndrome
3. Mice & Rats
4. Far East, Scandinavia & E. Europe
5. severe pulmonary syndrome (Sin Nombre)

Front 91

Congo-Crimean H.F.
1. Genus
2. Symptoms
3. Reservoir
4. Vector
5. Region

Back 91

1. Niavirus
2. Fever & Hemorrhage
3. Rodent
4. Tick
5. Asia & Africa

Front 92

Filoviridae
1. Family
2. Filovirus
3. Genome
4. Baltimore
5. Viruses that cause H.F. (2)
6. mortality
7. reservoir

Back 92

1. Filoviridae
2. Filovirus
3. ss - RNA long filamentous virus
4. Class V
5. Marburgvorus & Ebolavirus
6. 20-90%
7. UNKNOWN

Front 93

Marburg virus
1. Family
2. Symptoms (3)
3. May lead to
4. Reservori
5. Vecto
6. Mortality
7. Pathogenesis (site + 3 steps)

Back 93

1. Filovirus
2. Fever, Rash & Hemorrhage
3. DIC
4. n/a
5. N/A
6. 20%
7. Liver, Spleen, Liver & Lungs → Destruction of Parenchyma → Edema → Hypovolemic Shock

Front 94

Ebolavirus
1. Symoroms (3)
2. Region (2)
3. Pathogenesis (3 steps
4. Highest to lowest pathogenic strains (3)

Back 94

1. Sudan Ferbile illness → VAscular collapse → Internal Bleeding→ Death
2. Sudan & Zaire
43. Glycoprotein peplomers → Destrcution of Endothelium → Massive Hemmorhage
4. Zaire>Sudan>Cote d'Ivoire