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5 Cards in this Set

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Corynebacterium diptheria and Listeria monocytogenes are 2 G+ nonspore forming rods. TRUE/FALSE
TRUE.
What can be said of C. diptheria?
It is a pathogen responsible for diptheria. It colonizes the pharynx, forming a pseudomembrane composed of fibrin, leukocytes, epithelial cells and C. diptheria cells. From here the bacteria release an exotoxin into the bloodstream which damages the heart and neural cells by interfering with protein synthesis.
How is diptherious pharangitis different from that of strep throat/
In C. diphtheria the inflammatory exudate on the on the pharynx which appears darker and thicker than that of strep throat. The scraping of the membrane may result in the systemic lethal absorption of the exotoxin.
How is C. diphtheria confirmed?
Swab of the pharynx on potassium tellurite agar and Loefflers coagulated blood serum media. This test confirmation may require up to 1 week.
What is the therapeutic protocol?
1. Antitoxin- The C.. diphtheria antitoxin only inactivates circulating toxin, which has not yet reached target tissue. This must be done quickly.
2.-penicillin/Erythromycin-either will kill the bacteria, preventing further exotoxin release and rendering the patient non-contagious.
3.-DPT vaccine- The child must receive the DPT vax, as infection does not always infer protection in the future.