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42 Cards in this Set
- Front
- Back
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Chapter 18: Pseudomonas
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Chapter 18
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pseudomonas characteristics
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nonfermenting, aerobic, motile, Gram negative bacillus, ubiquitous in natural environment especially water and soil
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pseudomonas most frequently encountered in these individuals
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hospitalized patients
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pseudomonas enters through
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abrasions in skin, contaminating devises, or GI invasion
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those who are especially at risk are
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neutropenic, cancer pt, CF pt
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limits infection from pseudomonas
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neutrophils
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allows pseudomonas to spread and adhere to tissues
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biofilm
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mediates damage from pseudomonas
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exotoxin A (like diptheria toxin) and several proteases , T3SS that delivers virulence factors directly to host cells
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of critical imortance in deciding how to treat pseudomonas
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antibiotic resistance testing
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treatment for pseudomonas
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extended spectrum betalactam, aminoglycosides, and flouroquinalones
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deep puncture wounds can cause these conditions from pseudomonas infection
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osteomyelitis and cellulitis
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chronic cutaneous ulcers from pseudomonas can occur in patients with
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diabetes and those with impaired local circulation
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does pesudomonas ferment lactose
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no
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oxygen status of pseudomonas
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erobic
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motility of pseudomonas
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motile
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what distinguishes pseudomonas on culture
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distinctive pigmentation on solid media
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nutritional requirements
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minimal, makes them hard to kill off
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pyocyanin and pyoverdin
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water soluble pigments of pseudomonas
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capsule of pseudomonas composed of
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alginate
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pseudomonas relies on what to cause infection
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breakdown of normal host defenses
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predisposes one to pseudomonas folliculitis
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bathing in contaminated hottubs
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infection caused by pseudomonas in swimmers
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otitis externa
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can cause urinary tract infection from pseudomonas
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indwelling catheters
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how do pesudomonas move
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flagella and twitching motility/swarming motility of pilli
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type 4 pili important for formation of what
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biofilm
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adherence to epithelium due to interaction with what surface receptor
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asialo GM1
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initiates immune response to pseudomonasl
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TLR5
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LPS of pseudomonas interacts with what receptors
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CFTR ; can triger internalization
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patients with this immune defect are at highest risk for pseudomonas
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neutropenia
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allow pseudomonas to acquire iron from host
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siderophores
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rhamnolipid
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biosurfactant seceted by pseudomonas to damage membranes to make nutrients more available to it
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how does pseudomonas acquire phosphate
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production of phospholipase C
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MOA of exotoxin A
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ADP ribosylation of EF2 which results in a blockade of protein synthesis
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elastase
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zinc metalloprotease that degrades elastin
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LasA
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serine protease that works synergesticly to degrade elastin
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type 3 secretion system
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P. aeruginosa uses this to inject exotoxins directly into host cells
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ExoS causes
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rounding of cells
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ExoT causes
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interference of internilization of P aerugonisa by epithelium and macrophage
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exoy causes
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aenly cyclase activiy
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exo U causes
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cell lysis associated with more severe disease
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quorum sensing activity of p aerugonisa
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results from production of autoinducers which can diffuse out other bacteria
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resistance of pseudomonas to antimicrobials is due to
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limited outer membrane permeability and MDR pumps
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