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27 Cards in this Set
- Front
- Back
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Niesseria gonorrheae virulent factors
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Pilus, Por I (protein I), Opa (portein II), Rmp (protein III), lipoligosaccharide (LOS)
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Pilus virulent factor
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mediates attachment to non-ciliated human cells, interferes with neurophil killing.
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Por I (protein I) virulent factor
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stable prin protein that forms pores inouter membrane; used for serotype classification
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Opa (protein II) virulent factor
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mediates firm attachment to eukaryotic cells
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Rmp (protein III) virulent factor
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reduction-modificable protein. products other surface antigens from antibodies
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definition of phase variation
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reversible loss or gain of a molecule or defined structure
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definition of antigenic variation
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change in the composistion or structure of a molecule
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mechanism for variation
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modulation of gene expression, recombination, error in repplication (slipped-strand synthesis)
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host response to Neisseria gonorrheae
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neutrophils and sloughing of the epthelium with formation of microabsesses, male exudate (contiansh ost inflammatory cells). eventually macrophages and lymphoctyes replace neutrophils, and gonorrhoeae can no longer be identified histlogically
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asymptomatic carriers of Neisseria gonorrhoae
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50% of women are carriers, and 15% of men are carriers
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local infections of Neisseria gonorrhoae
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urtheral discharge and dysuria for men. cervicitis, with increased vaginal dischage, intermenstrual bleeding for women
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invasion into sex organs - Neisseria gonnorhoae
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men - epididymitis female - pelvic inflammatory disease caused by spread of organisms along fallopian tube and pelvic cafity. can cause infertility, ectopic pregnancy, scarring fallopian tube
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invasion into blood stream - Neisseria gonorrhoae
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conjunctivitis (ophthalmia neonatorum) endocarditis, osteomyelitits, meningtitis, arthritis-dermaticis,
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DGI
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organisms disseminate, cause skin lesions or joint pain
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identification
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gram negative diplocci that grows as mcoidy colonies, oxidase positive, sugar fermentation (acid produced from glucose and not other sugars)
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Neisseria gonorrhoae treatment
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ceftriaxone or spectinomycin, plus doxycycline (neonates - 1% silver nitrate as a prophylaxis agasint ophthalmia neonatorum)
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Neisseria meningitidis
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inflammatory disease of the CNS caused by growth of bacteria in the leptomeninges
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Epidemiology of Neisseria meningitidis
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predominantly pediatric illness, happens in crosed environments (day care cetners, college dormitories, hospitals, military barracks)
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serogrouping of Neisseria miningitidis
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A - cause epidemics
B&C - endemic Y - pulmonary disease W 135 - cause bacteremia |
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pathogenic factors for N. meningitidis
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adheres to nasopharnx by Pilus, has specific serotype antibodies, protected by capsule so no antibody mediated phagocytosis, LOS endotoxin effects are expressed
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N. meningitidis transient bacteremia
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no sequelae
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N. meningititis chronic meningococcemia
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transient bacteremia, often with arthritis and pustular dermatitis, low-grade ferver, peterchial skin lesions
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N. meningititis acute
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abrupt onset of fever, worse headache ever, stiff neck, coma, vomitting, petechial skin lessions
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N. meningititis fulminant
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intravascular coagulation, circulatory collapse, adn death within a few hours
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N. meningitis laboratory diagnosis with CSF
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elevated leukocyte count consisting of predominately PMNs associated with low glucose in CSF,
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N. meningitits laboratory identification
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culture specimen on nonselective chocolate agar. gram-negative diplococci in polymorphonuclear leukocytes, oxidase positive, sugar fermentation and lfuorescent antiobdy staining
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N. meningitis treatment
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penicillin G - meningococall meningitis, meningococcemia
fulfonamide (or rifampin for sulfonamide-resistance strains)- household and intimate contacts |
