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68 Cards in this Set
- Front
- Back
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What order are mice in?
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Rodentia
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What family are mice in?
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Muridae
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What is the genus of mouse?
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Mus
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What is the genus and species of the lab mouse?
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Mus musculus
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What does FISH stand for?
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Fluorescent in situ hybridization
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The major histocompatibility complex is on what chromosome(s)
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Chromosome 17
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The minor histocompatibility complex is on what chromosomes?
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Multiple chromosomes
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The major histocompatibility complex is associated with what type of rejection?
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Rapid
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The minor histocompatibility complex is associated with what kind of rejection?
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Delayed
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How do you perpetuate inbred strains
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Brother sister matings
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How do you perpetuate F1 hybrids?
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Cannot be perpetuated
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What is a coisogenic inbred strain?
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Occurrence of a mutation within a strain
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What is a segregating inbred strain?
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Inbred strain with forced heterozygosity for mutations
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How do you "force" heterozygosity?
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Backcrossing, intercrossing, or crossing and intercrossing
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What is a congenic inbred strain?
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Strain where gene of interest is transferred from one strain to another by repeated backcrossing
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What is an easy way to produce an outbred strain?
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Circular mating system
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How rapidly does heterogeneity decrease?
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for every 25 breeding pairs, heterogeneity decreases 1% per generation
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What is the advantage of a recombinant inbred strain?
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Control for environmental variability
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Do mouse bronchi have cartilage?
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Yes
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What is the thermoneutral zone for mice?
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29.6 to 30.5 C
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What ambient temp range results in good breeding data?
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21 to 25 C
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Do mice have sweat glands?
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No
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Describe lung anatomy for mice.
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Left lung is one lobe; right lung has 4 lobes
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Who has more glomeruli in the kidneys, rats or mice?
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Mice (4.8 times more than rat)
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Is creatinine typically excreted in the urine?
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Yes
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Mouse urine concentration is
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4300 mOsm/liter
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Human urine concentration is
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1160 mOsm/liter
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Describe submaxillary salivary gland secretions
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seromucoid only
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Describe mouse stomach
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proximal keratinized; distal glandular
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Define "gnotobiotic"
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Defined flora
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What is Schaedler flora?
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Defined flora given to gnotobiotic animals
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When should thymectomy be performed
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Neonatal
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MALT?
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Mucosa associated lymph tissue (e.g. Peyer's patches, cecal lymphoid tissue)
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When does thymus involute?
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between 35 to 80 days of age
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Which spleen is larger, male or female?
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male (up to 50%)
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Does the mouse have tonsils?
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Doesn't have palatine or pharyngeal tonsils
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What is mouse dental formula?
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1003/1003
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Which teeth grow continuously?
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Incisors only
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How many mammae for mice?
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5 (3 thoracic, 2 abdominal)
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What are the clitoral glands homologous to?
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Preputial glands
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What are male accessory glands?
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seminal vesicle, coagulating gland, prostate, bulbourethral, preputial
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What is effect of FSH?
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Promote gametogenesis
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When does ovarian maturity occur?
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By 30 days of age
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When does male puberty occur?
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around 45 days of age
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Mouse estrous cycle
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3-5 days, polyestrous
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Postpartum estrus?
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14-24 hours after parturition
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Spontaneous or induced ovulator?
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spontaneous
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What is Whitten effect
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Estrus suppression in group of females
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What is Bruce effect
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Failure to implant in recently bred female exposed to novel male
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What is Lee-Boot effect
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Return to estrus when new male introduced
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Which hormone stimulates CL progesterone production?
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Prolactin (after coital stimulation)
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Gestation length?
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19-21 days
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Common age to retire breeders
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1 year
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When does lactation peak?
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12 days postpartum
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When does passive immunity cease during lactation?
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It doesn't - antibodies throughout lactation
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What is role of IgM
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Initial exposure to antigen
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What is role of IgG
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Repeated exposure to antigen
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What is role of IgA
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Mucosal immunity
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What is role of IgE
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Role in allergy
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What is role of IgD
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Unclear
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CD4+ cells are
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Helper cells (MHC Class II restricted)
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CD8+ cells are
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Cytotoxic cells (MHC class I restricted)
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What is Nude mouse deficient in?
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T cells (lack thymus)
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What is SCID mouse deficient in?
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T and B cells (defective receptors)
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What are Rag-1 and Rag-2 mice deficient in?
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Ig and T cell responses
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What is XID mouse deficient in?
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B cells (defective signal transduction)
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What is moth eaten mouse deficient in?
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cytotoxic T cells and NK cells
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What is beige mouse deficient in?
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type II pneumocytes, mast cells, and NK cells
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