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17 Cards in this Set

  • Front
  • Back
Define biofilm
organized bacterial community enmeshed in matrix of extracellular polymeric substances (EPS)
What is EPS composed of?
Polysaccharides, proteins, nucleic acids
define quorum sensing
coordinated chemical signalling
Define autoinducer
signaling molecule used in quorum sensing
Define planktonic
single bacterial cells growing in fluid
Why would bacteria deeper in the biofilm have different physiology?
O2 and nutrient availability
What % of infections that physicians encounter are biofilm?
Give two examples of locations for benign environmental biofilms. What problems do they cause?
Rocks, ship hulls. Corrosion
Give four examples of medical devices affected by biofilms
heart valve implants
hemodialysis equipment
dental implants
Give six examples of human biofilms that cause disease
Cystic Fibrosis in lung
Urinary tract
Oral biofilms
What causes cystic fibrosis? Where located?
biofilm of Pseudomonas aeruginosa in lung
What causes tuberculosis?
Mycobacterium tuberculosis
What causes ur. tract infections?
Escherichia coli
What environmental biofilms impact human health?
hot water systems in hospitals (mycobacterium avium)
Drinking h20 reservoirs (Salmonella typhimurium)
T/F: Bacillus anthracis is attracted to biofilms on copper tubing
Give three reasons for increased resistance to antibiotics of biofilms
1) EPS matrix impedes penetration
2) Nutrient and O2 availability make interior bacteria metabolically inactive
3) Persister cells remain viable and allow biofilm to persist
Give three new approaches to anti-biofilm therapy
1) Interfering with EPS synthesis
2) Inhibiting biofilm adherence to the substrate (ie coating medical devices in chemical)
3) Targeting autoinducers (no signalling)