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12 Cards in this Set
- Front
- Back
Causes of secondary Hyperparathyroidism
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Decrease serum calcium: Renal Failure, inadequate diet, steatorrhea, Vit D deficiency
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Causes of Hypoparathyroidism
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surgically induced, congenital absence, familial, Idiopathic(CASR)
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Familial Hypoparathyroidism
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APS1(Autoimmune poly-endocrine syndrome), mutation in AIRE, get mucocutaneous Candidiasis, primary adrenal insufficiency
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Clinical manifestation of Hypoparathyroidism
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Tetany: Chvostek and trousseau sign, mental status changes, intracranial calcifications (parkinsons), cataracts, dental, prolonged QT
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Clinical manifestation of pseudohypoparathyroidism
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end-organ Unresponiveness of Kidney to PTH, shortened 4th and 5th metatarsals/carpals
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Causes of secondary Hyperparathyroidism
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Decrease serum calcium: Renal Failure, inadequate diet, steatorrhea, Vit D deficiency
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Gene involved with pseudoypoparathyroidism
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GNAS1, codes for g-protein, in kidney and pituitary only maternal allele is expressed(imprinting)
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Causes of Hypoparathyroidism
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surgically indused, congenital absence, familial, Idiopathic(CASR),
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|
Familial Hypoparathyroidism
|
APS1(Autoimmune poly-endocrine syndrome), mutation in AIRE, get mucocutaneous Candidiasis, primary adrenal insufficiency
|
|
Clinical manifestation of Hypoparathyroidism
|
Tetany: Chvostek and trousseau sign, mental status changes, intracranial calcifications (parkinsons), cataracts, dental, prolonged QT
|
|
Clinical manifestation of pseudohypoparathyroidism
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end-organ Unresponiveness of Kidney to PTH, shortened 4th and 5th metatarsals/carpals
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Gene involved with pseudoypoparathyroidism
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GNAS1, codes for g-protein, in kidney and pituitary only maternal allele is expressed(imprinting)
|