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12 Cards in this Set

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Causes of secondary Hyperparathyroidism
Decrease serum calcium: Renal Failure, inadequate diet, steatorrhea, Vit D deficiency
Causes of Hypoparathyroidism
surgically induced, congenital absence, familial, Idiopathic(CASR)
Familial Hypoparathyroidism
APS1(Autoimmune poly-endocrine syndrome), mutation in AIRE, get mucocutaneous Candidiasis, primary adrenal insufficiency
Clinical manifestation of Hypoparathyroidism
Tetany: Chvostek and trousseau sign, mental status changes, intracranial calcifications (parkinsons), cataracts, dental, prolonged QT
Clinical manifestation of pseudohypoparathyroidism
end-organ Unresponiveness of Kidney to PTH, shortened 4th and 5th metatarsals/carpals
Causes of secondary Hyperparathyroidism
Decrease serum calcium: Renal Failure, inadequate diet, steatorrhea, Vit D deficiency
Gene involved with pseudoypoparathyroidism
GNAS1, codes for g-protein, in kidney and pituitary only maternal allele is expressed(imprinting)
Causes of Hypoparathyroidism
surgically indused, congenital absence, familial, Idiopathic(CASR),
Familial Hypoparathyroidism
APS1(Autoimmune poly-endocrine syndrome), mutation in AIRE, get mucocutaneous Candidiasis, primary adrenal insufficiency
Clinical manifestation of Hypoparathyroidism
Tetany: Chvostek and trousseau sign, mental status changes, intracranial calcifications (parkinsons), cataracts, dental, prolonged QT
Clinical manifestation of pseudohypoparathyroidism
end-organ Unresponiveness of Kidney to PTH, shortened 4th and 5th metatarsals/carpals
Gene involved with pseudoypoparathyroidism
GNAS1, codes for g-protein, in kidney and pituitary only maternal allele is expressed(imprinting)