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10 Cards in this Set
- Front
- Back
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Where does oxygen bind to on haemoglobin? |
Haem groups |
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What happens to myoglobin structure when oxygen binds to it? |
Fe moves from below the plane into the plane. Small change in overall protein shape. |
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Myoglobin vs haemoglobin draw the graphs |
Hyperbolic vs sigmoidal. |
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Is the R state high or low affinity |
High. It's stabilised when oxygen binds to the Hb |
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Is t state high or low affinity? |
Low |
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Why is the O2 binding curve for haemoglobin sigmoidal? |
Because binding affinity for oxygen increases as more O2 molecules bind. So oxygen can be released at the tissues. |
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What binds to haemoglobin and causes decreased affinity for O2? |
2,3-BPG. 1 per Hb molecule. |
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Describe the Bohr effect |
Binding of CO2 and H+ to haemoglobin lowers affinity for oxygen. |
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Describe how metabolically active tissues ensure O2 release. |
They produce large amounts of H+ and Co2. Ensures oxygen is released at these tissues. |
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Why is carbon monoxide poisonous? |
Binds to Hb 250x more readily than O2, does not dissociate. Fatal when COHb is >50% |
