Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
8 Cards in this Set
- Front
- Back
|
What is the mechanism of antimicrobial activity of Metronidazole?
|
Activation via bacterial pyruvate ferrodoxin oxidoreductase
Double-stranded breaks in bacterial DNA Bacteriacidal |
|
|
What determines the selectivity of Metronidazole?
|
It needs to be reduced by pyruvate: ferredoxin oxxidoreductase.
So whatever bugs have this enzyme, will be KILLED by the drug |
|
|
What is the absorption of metronidazole?
|
Orally
|
|
|
Where does the metabolism of Metrondiazole take place?
|
The liver via P450 enzymes (think side effects here to clue in to where the metabolism takes place)
The half life is 8 hr. |
|
|
What component of the body does Metronidazole penetrate particularly well?
|
The CSF
|
|
|
How is Metronidazole excreted?
|
Renally
|
|
|
What are the five adverse effects of Metronidazole?
|
GI irritation
Metallic taste Disulfiram-like effect with alcohol CNS effects Drug interactions: can potentiate the anticoagulant effect of warfarin (P450) |
|
|
What are the clinical uses of Metronidazole?
|
Anaerobic infections
Protozoal infections H. pylori Orally for C. difficile |
