Metabolism -- Pentose Phosphate Pathway

Front 1

What is the most common enzymophathy

What is the most common manifestation of this disease?

Back 1

1) G6PDH

2) Hemolytic anemia in adults (due to hemolysis), jaundice in infants

Front 2

1) What compound protects RBCs against oxidative damage?

2) What enzyme regenerates this comound?

3) What cofactor is necessary for this regeneration?

Back 2

1) Reduced Glutatione (GSH)

2) Glutathione Reductase

3) NADPH, H

Front 3

Generally:

1) NADPH is used in _____ rxns

2) NAD+ is used in _____ rxns

Back 3

1) reductive, synthetic

2) oxidative, degradative

Front 4

The oxidative branch of the pentose phosphate pathway involves what two enzymes?

Is this part of the pathway reversible?

Back 4

1)G6PDH (regulatory)
6-phosphogluconate dehydrogenase (decarboxylation)

2) No

Front 5

Alternative uses of the Pentoses of the Pentose Phosphate Pathway.

Back 5

1) Sythesis of ribose-5-Pi
2) Conversion to glucose-6-Pi
3) Metabolism to lactate (via Glyceraldehyde-3-phosphate linkage to glycolysis)

Front 6

Glyceraldayde-3-phosphate is a metabolite in both ______ and ____

Back 6

Glycolysis and Gluconeogenisis

Front 7

The pentose phosphate pathway is the only source of _____ in red cells

Back 7

NADPH