Metabolism: 1.17 Hmp Shunt, Pentose Phosphate Pathway, Phosphogluconate Pathway

Front 1

Describe how galactose & fructose are channeled into glycolysis.

Back 1

-Galactose binds as UDP-galactose, goes thru epimerase to become UDP-glucose & released into glycolysis as glucose-1-P

fructose enter as fructose-6-P, main regulatory step
-or can enter later as glyceraldehyde-3-P (skip regulation)

Front 2

Identify 2 important products of the pentose phosphate pathway.

Describe roles in:
-biosynthesis
-replication
-energy metabolism

Back 2

1. Ribose-5-P
2. NADH

-synthesis of nucleic acids
-energy for biosynthesis

-essential to genomes & RNA
-essential to metabolic cofactors (NAD, FAD, NADP, CoA)

Front 3

Determine whether given rxn from HMP shunt is part of oxidative phase or non-oxidative phase?

Back 3

-oxidative phase: creates NADPH

-non-oxidative phase: rearrangement (transferketoase/transferaldolase)

Front 4

Describe regulation & coordination of pentose phosphate path w/ glycolysis & identify where these paths interconnect.

Back 4

-Glucose-6-P fed into HMP shunt

-build up of glycolysis/gluconeo products (shortage of NADPH or Ribose = increase HMP shunt fxn)
-HMP shunt products go into glycolysis as: F-6-P or Glyceraldehyde-3-P