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8 Cards in this Set
- Front
- Back
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Arsenic (glycolysis) |
Can replace the Pi in G3P----> 1,3BPG rection which sopes the generation of the first ATP Results in lose of 2ATP per on round of Glycolysis Still get pyruvate |
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Arsenic (Pyruvate) |
It inhibits pyruvate dehydrogenase which catalyses Pyruvate -----> Acetyl-CoA The Pyruvate goes to lactate which lowers the amountof AT being made furture and decreases the pH (lactate is a acid) causing acidosis |
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1080 (Sodium Fluoroacetate) |
Replaces Acetyl-CoA in the generaion of Citrate to make Fluorocitrate which then inhibits the Aconitase enzyme which catalyses the Citrate ----> Isocitrate reaction No reduced co-enzymes and GTP made from the CAC and ATP output is dramatically reduced. |
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Dinitrophenol (DNP) Uncoupling protein |
Plants in the inner mitochondrial memberane and transports H+ from the IMS to the Matrix. Disapates Electrochemical gradient (PMF) and stops/slows down the ATPase's production of ATP Releases energy as heat |
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Cyanide |
Binds to Cyt-a3 in complex of the ETC It is the last electron acceptor before oxygen so it blocks the ETC and causes a back up which inhibits the rest of the ETC and stops the electrochemical gradient from being generated. No ATP synthesis |
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Rotenone |
Inhibits complex 1 and stops the ETC from using NADH as an electron donor Less H+ being pumped but FADH2 can still be used in complex 2 to power complex 3 which pumps H+ |
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Malonate |
Inhibits complex 2 and stops the ETC from using FADH2 as a electron donor Less power provided to pump H+ in complex 3 but NADH can still be used in complex 1 to pump H+ |
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Carbon monoxide |
Mimicks O2 at the end of the ETC BUT will not accept electrons Causes a back-up in the ETC and stops the co-enzymes from being regenerated and H+ gradient disipates. No ATP made |
