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14 Cards in this Set
- Front
- Back
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Overflow of urate can lead to?
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crystals in joints, gout
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Overflow of uric acid can lead to?
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uric acid stones, kidney stones
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What drug inhibits hypoxanthine to urate?
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allopurinol
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What drug favors uric acid?
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probenecid
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What drug degrades urate to allantoin?
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rasburicase
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PRPP is used for?
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1.de novo synthesis of purine nucleotides.
2.de novo synthesis of pyrimidine nucleotides. 3.salvage of purines 4.synthesis of NAD and NADP |
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PRPP goes to IMP by?
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glutamine PRPP amidotransferase which is regulated by PRPP and inhibited by ^ AMP
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Who competes with urate for excretion?
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Organic acids(lactate, B-hydroxybutyrate, acetoacetate)
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For salvage to occur what is needed?
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PRPP and hypoxanthine, (enzyme for salvage is HGPRT)
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If hypoxanthine is available, PRPP is used for?
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Salvage (preferred over de novo)
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What regulates the synthesis of AMP to Hyx?
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cytotoxic agents(chemo), high AMP
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What inhibits the synthesis of urate to urine?
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diuretics, organic acids, and kidney damage
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Where does degradation of hypoxanthine to urate occur?
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liver and intestine
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How much urate is excreted per passage through the kidney?
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7-10%
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