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9 Cards in this Set
- Front
- Back
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Two methods of neurotransmitter inactivation:
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-neurotransmitter reabsorbed intot he presynaptic neuron where it had been released.
-enzyme dissolves neurotransmitter. |
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7 classes of psychotropic drugs:
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-antidepressants
-mood stabilizers -antiParkinsonian agents -anxiolytic agents -psychostimulants -drugs for senile dementia -treatment for substance abuse |
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ANTIDEPRESSANTS
Indications |
dysthymic disorder, major depression, depression associated with organic disease, alcoholism, schizophrenia, mental retardation, depressive phases of bipolar, depression accompanied by anxiety
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ANTIDEPRESSANTS
Action |
Increase concentration of norepinephrine and serotonin in the body, either by BLOCKING their reuptake by the neurons or by INHIBITING the release of MAOI. **specifically in cleft**
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ANTIPSYCHOTICS
Indications |
Treatment of acute and chronic psychoses; selected agents are also used antiemetics in the treatment of intractable hiccups and for control of tics and vocal utterances in Tourette's.
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Tricyclics (TCAs)
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-dirty drugs; PET Pamelor, Elavil, Tofronil
-used for severe depression, panic attacks, OCD, severe pain -anticholinergic side effects: blood dyscrasias, cardiotoxicity -risk of mortality is high w/ OD -discontinuation syndrome |
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Interactions with Tricyclics
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-increased effects of tricyclics with buproprion, cimetidine, haloperidol, SSRIs, and valproic acid
-decreased effects with rifamycin, carbamazepine, barbituates -hyperpyretic crisis, convulsions, death can occur with MAOIs -hypertensive crisis with clonidine -decreased levodopa, guanethidine -potentiation of pressor response with direct-acting sympathomimetics |
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Monoamine oxidase inhibitors (MAOIs)
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-most common: Nardil, Parnate, Marplan
-DANGER: tyramine buildup resulting in HTN crisis -monitor BP first 6 weeks -edema, sexual dysfunction, wt gain, insomnia, confusion, parathesia. -LAST RESORT ANTIDEPRESSANT |
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MAOI Interactions
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-HTN crisis with amphetamines, methyldopa, levodopa, dopamine, epinephrine, norepinephrine, reserpine, vasoconstrictors, food with tyramine
-HTN, hypotension, coma, convulsions, death with narcotic analgesics, -additive hypotension with antihypertensives -additive hypoglycemia with antihyperglycemic agents -potentially FATAL reactions with other antidepressants, carbamazepine, cyclobenzaprine, maprotiline, procarbazine, selegiline (two weeks apart) |
